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Artículo

Allostatic-Interoceptive Overload in Frontotemporal Dementia

Birba, AgustinaIcon ; Santamaría García, Hernando; Prado, Pavel; Cruzat, Josefina; Sainz Ballesteros, Agustín; Legaz, AgustinaIcon ; Fittipaldi, Sol; Duran Aniotz, Claudia; Slachevsky, Andrea; Santibañez, Rodrigo; Sigman, MarianoIcon ; García, Adolfo MartínIcon ; Whelan, Robert; Moguilner, Sebastian Gabriel; Ibañez, Agustin MarianoIcon
Fecha de publicación: 05/2022
Editorial: Elsevier Science Inc.
Revista: Biological Psychiatry
ISSN: 0006-3223
e-ISSN: 1873-2402
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

BACKGROUND: The predictive coding theory of allostatic-interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs and environmental demands. These functions seem to be distinctly compromised in behavioral variant frontotemporal dementia (bvFTD), including alterations of the allostatic-interoceptive network (AIN). Here, we hypothesize that bvFTD is typified by an allostatic-interoceptive overload. METHODS: We assessed resting-state heartbeat evoked potential (rsHEP) modulation as well as its behavioral and multimodal neuroimaging correlates in patients with bvFTD relative to healthy control subjects and patients with Alzheimer’s disease (N = 94). We measured 1) resting-state electroencephalography (to assess the rsHEP, prompted by visceral inputs and modulated by internal body sensing), 2) associations between rsHEP and its neural generators (source location), 3) cognitive disturbances (cognitive state, executive functions, facial emotion recognition), 4) brain atrophy, and 5) resting-state functional magnetic resonance imaging functional connectivity (AIN vs. control networks). RESULTS: Relative to healthy control subjects and patients with Alzheimer’s disease, patients with bvFTD presented more negative rsHEP amplitudes with sources in critical hubs of the AIN (insula, amygdala, somatosensory cortex, hippocampus, anterior cingulate cortex). This exacerbated rsHEP modulation selectively predicted the patients’ cognitive profile (including cognitive decline, executive dysfunction, and emotional impairments). In addition, increased rsHEP modulation in bvFTD was associated with decreased brain volume and connectivity of the AIN. Machine learning results confirmed AIN specificity in predicting the bvFTD group. CONCLUSIONS: Altogether, these results suggest that bvFTD may be characterized by an allostatic-interoceptive overload manifested in ongoing electrophysiological markers, brain atrophy, functional networks, and cognition.
Palabras clave: ALLOSTASIS , ALLOSTATIC-INTEROCEPTIVE NETWORK , FRONTOTEMPORAL DEMENTIA , HEP , INTEROCEPTION , MULTIMODAL IMAGING , PREDICTIVE CODING , rsHEP
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/234392
URL: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01042-3/fullte
DOI: https://doi.org/10.1016/j.biopsych.2022.02.955
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Birba, Agustina; Santamaría García, Hernando; Prado, Pavel; Cruzat, Josefina; Sainz Ballesteros, Agustín; et al.; Allostatic-Interoceptive Overload in Frontotemporal Dementia; Elsevier Science Inc.; Biological Psychiatry; 92; 1; 5-2022; 54-67
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