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dc.contributor.author
Dorrego, Camila Iris  
dc.contributor.author
Pellice, Silvana  
dc.contributor.author
Carauni, Ana Lisa  
dc.contributor.author
Chiapella, Luciana Carla  
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Dapena, Gimena  
dc.contributor.author
Chamartin, Pablo  
dc.contributor.author
Rocco, Franco Daniel  
dc.contributor.author
Alezzandrini, Arturo Alberto  
dc.date.available
2024-04-23T13:16:19Z  
dc.date.issued
2023-06  
dc.identifier.citation
Dorrego, Camila Iris; Pellice, Silvana; Carauni, Ana Lisa; Chiapella, Luciana Carla; Dapena, Gimena; et al.; Association Between Biomarkers in Optical Coherence Tomography and Visual Acuity in Patients with Edema Diabetic Macular Treated with Antiangiogenics; ECronicon; EC Ophtalmology; 14; 7; 6-2023; 1-14  
dc.identifier.issn
2453-188X  
dc.identifier.uri
http://hdl.handle.net/11336/233870  
dc.description.abstract
Purpose: To evaluate the association between the main bio- markers of Diabetic Macular Edema (DME) and the Visual Acuity (VA), and determine its importance as a prognostic tool at time to start an antiangiogenic treatment in each patient. Methods: Retrospective, observational and longitudinal cohort study. 25 OCT scans of 23 patients with diabetic macular edema (DME) were analyzed, and the Best Corrected Visual Acuity (BCVA) at baseline and at 3, 6 and 9 months of treatment was registered. Baseline images were evaluated for predominant type of macular edema (cystoid, spongiform, with subfoveal serous detachment, or tractional compromise); presence of outer retinal damage (ORD, considered as any discontinuity in Limiting Extern Membrane, Ellipsoid Zone, and/or Interdigitation Zone); presence of disorganization of the Inner Retinal Layers (DRIL), and Hyperreflective Focus (HF) quantity, as well as Central Macular Thickness (CMT). Correlations between each OCT biomarker and visual acuity gain were analyzed using longitudinal mixed-effects models. Results: Twenty five eyes with NAIVE DME were included. Baseline best-corrected visual acuity (BCVA) was between 0.3 and 1.3 on a logarithm of minimum angle of resolution visual chart (logMAR). Type of macular edema, DRIL presence, and CMT presented a statistically significant effect on the VA modification along the time (p < 0,001 in all cases). Patients with DRIL showed worse VA in logMAR terms at 9 months than patients without DRIL, being the difference statistically different (p = 0,026), and showed less improvement in VA along the nine months treatment (interaction effect p = 0,007). Eyes with subfoveal serous detachment and eyes with tractional component gained less vision than patients with only cystoid macular edema. There were no statistically significant differences between presence of hyperreflective focus, extern retinal layers alteration and VA along the treatment time. Conclusion: This study showed that it is useful to assess the initial CMT but not in isolation, and above all the presence of DRIL, which proved to be the tomographic biomarker with the greatest potential as a predictor of clinical response in terms of VA.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
ECronicon  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Diabetic Macular Edema  
dc.subject
OCT  
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Biomarkers  
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DRIL  
dc.subject.classification
Oftalmología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Association Between Biomarkers in Optical Coherence Tomography and Visual Acuity in Patients with Edema Diabetic Macular Treated with Antiangiogenics  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-04-08T11:20:46Z  
dc.journal.volume
14  
dc.journal.number
7  
dc.journal.pagination
1-14  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
London  
dc.description.fil
Fil: Dorrego, Camila Iris. Sanatorio "Otamendi y Miroli S. A."; Argentina. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Pellice, Silvana. Sanatorio "Otamendi y Miroli S. A."; Argentina. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Carauni, Ana Lisa. Sanatorio "Otamendi y Miroli S. A."; Argentina. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Chiapella, Luciana Carla. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina  
dc.description.fil
Fil: Dapena, Gimena. Sanatorio "Otamendi y Miroli S. A."; Argentina. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Chamartin, Pablo. Sanatorio "Otamendi y Miroli S. A."; Argentina. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Rocco, Franco Daniel. Universidad de Buenos Aires; Argentina. Sanatorio "Otamendi y Miroli S. A."; Argentina  
dc.description.fil
Fil: Alezzandrini, Arturo Alberto. Oftalmos Centro Oftalmológico de Alta Complejidad; Argentina. Universidad de Buenos Aires; Argentina  
dc.journal.title
EC Ophtalmology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ecronicon.net/assets/ecop/pdf/ECOP-14-00991.pdf  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ecronicon.net/ecop/association-between-biomarkers-in-optical-coherence-tomography-and-visual-acuity-in-patients-with-edema-diabetic-macular-treated-with-antiangiogenics