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dc.contributor.author
Biscari, Lucía  
dc.contributor.author
Maza, M. Carmen  
dc.contributor.author
Farré, Cecilia  
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Kaufman, Cintia Daniela  
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Amigorena, Sebastian  
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Fresno, Manuel  
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Gironès, Núria  
dc.contributor.author
Alloatti, Andrés  
dc.date.available
2024-04-23T10:45:23Z  
dc.date.issued
2023-03  
dc.identifier.citation
Biscari, Lucía; Maza, M. Carmen; Farré, Cecilia; Kaufman, Cintia Daniela; Amigorena, Sebastian; et al.; Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi; Frontiers Media; Frontiers in Cell and Developmental Biology; 11; 3-2023; 1-9  
dc.identifier.issn
2296-634X  
dc.identifier.uri
http://hdl.handle.net/11336/233817  
dc.description.abstract
Antigen cross-presentation is a vital mechanism of dendritic cells and other antigen presenting cells to orchestrate the priming of cytotoxic responses towards killing of infected or cancer cells. In this process, exogenous antigens are internalized by dendritic cells, processed, loaded onto MHC class I molecules and presented to CD8+ T cells to activate them. Sec22b is an ER-Golgi Intermediate Compartment resident SNARE protein that, in partnership with sintaxin4, coordinates the recruitment of the transporter associated with antigen processing protein and the peptide loading complex to phagosomes, where antigenic peptides that have been proteolyzed in the cytosol are loaded in MHC class I molecules and transported to the cell membrane. The silencing of Sec22b in dendritic cells primary cultures and conditionally in dendritic cells of C57BL/6 mice, critically impairs antigen cross-presentation, but neither affects other antigen presentation routes nor cytokine production and secretion. Mice with Sec22b conditionally silenced in dendritic cells (Sec22b−/−) show deficient priming of CD8+ T lymphocytes, fail to control tumor growth, and are resistant to anti-checkpoint immunotherapy. In this work, we show that Sec22b−/− mice elicit a deficient specific CD8+ T cell response when challenged with sublethal doses of Trypanosoma cruzi trypomastigotes that is associated with increased blood parasitemia and diminished survival.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CROSS-PRESENTATION  
dc.subject
DENDRITIC  
dc.subject
SEC22b  
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MICE  
dc.subject.classification
Biología Celular, Microbiología  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-04-22T11:53:27Z  
dc.journal.volume
11  
dc.journal.pagination
1-9  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Biscari, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.description.fil
Fil: Maza, M. Carmen. Universidad Autónoma de Madrid; España  
dc.description.fil
Fil: Farré, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.description.fil
Fil: Kaufman, Cintia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.description.fil
Fil: Amigorena, Sebastian. Inserm; Francia  
dc.description.fil
Fil: Fresno, Manuel. Universidad Autónoma de Madrid; España  
dc.description.fil
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España  
dc.description.fil
Fil: Alloatti, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.journal.title
Frontiers in Cell and Developmental Biology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2023.1138571/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fcell.2023.1138571