Show simple item record

dc.contributor.author Moreno, Griselda Noemí
dc.contributor.author Errea, Agustina Juliana
dc.contributor.author Van Maele, Laurye
dc.contributor.author Roberts, Roy
dc.contributor.author Léger, Hélène
dc.contributor.author Sirard, Jean Claude
dc.contributor.author Benecke, Arndt
dc.contributor.author Rumbo, Martín
dc.contributor.author Hozbor, Daniela Flavia
dc.date.available 2017-08-31T19:07:16Z
dc.date.issued 2013-06
dc.identifier.citation Moreno, Griselda Noemí; Errea, Agustina Juliana; Van Maele, Laurye; Roberts, Roy; Léger, Hélène; et al.; Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection; Elsevier Masson; Microbes and Infection; 15; 10-11; 6-2013; 708-718
dc.identifier.issn 1286-4579
dc.identifier.uri http://hdl.handle.net/11336/23377
dc.description.abstract Most of the knowledge on the impact of Bordetella pertussislipo-oligosaccharide (LOS) on the infectious process was obtained when the bacteria was established within the host. The aim of the present work was to determine the role of TLR4 at a very early step of the infectious process. To this end we used a transcriptomic approach on B. pertussis intranasal infection model in C3H/HeN, a TLR4-competent mouse strain, and C3H/HeJ, a TLR4-deficient mouse strain. The expression of approximately 140 genes was significantly changed 2 h post-infection in the C3H/HeN animals compared to the C3H/HeJ animals, which were essentially non-responders at this early time point. Pathways specific for immunity and defense, chemokine- and cytokine-mediated functions and TLR signaling, were activated upon infection in the TLR4 competent mice either at 2 h or 24 h. Furthermore, we observed that TLR4 signaling is absolutely required to promote the rapid recruitment of neutrophils into the airways. Interestingly, the depletion of those neutrophils impacted on B. pertussislung counts in the first three days, thereby exacerbating the lung infection. In summary, we determined that TLR4 is a central player in initial neutrophil recruitment and orchestration of the very early innate defense against B. pertussis.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Masson
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Bordetella pertussis
dc.subject TLR4
dc.subject LPS
dc.subject Neutrophils
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-08-29T15:37:56Z
dc.journal.volume 15
dc.journal.number 10-11
dc.journal.pagination 708-718
dc.journal.pais Francia
dc.journal.ciudad París
dc.description.fil Fil: Moreno, Griselda Noemí. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Errea, Agustina Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina
dc.description.fil Fil: Van Maele, Laurye. Centre National de la Recherche Scientifique; Francia. Universite Lille 3; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil Fil: Roberts, Roy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
dc.description.fil Fil: Léger, Hélène. Institut des Hautes Études Scientifiques; Francia
dc.description.fil Fil: Sirard, Jean Claude. Universite Lille 3; Francia. Centre National de la Recherche Scientifique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil Fil: Benecke, Arndt. Institut des Hautes Études Scientifiques; Francia
dc.description.fil Fil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina
dc.description.fil Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
dc.journal.title Microbes and Infection
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.micinf.2013.06.010
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1286457913001251


Archivos asociados

Icon
Blocked Acceso no disponible

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)