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dc.contributor.author
Mukhomedzyanov, A. V.
dc.contributor.author
Popov, S. V.
dc.contributor.author
Maslov, L. N.
dc.contributor.author
Azev, V. N.
dc.contributor.author
Diez, Emiliano Raúl
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dc.date.available
2024-04-19T17:33:18Z
dc.date.issued
2023-04
dc.identifier.citation
Mukhomedzyanov, A. V.; Popov, S. V.; Maslov, L. N.; Azev, V. N.; Diez, Emiliano Raúl; The role of no synthase, MPT pore, and protein kinase a in the cardioprotective effect of the opioid receptor agonist deltorphin II; Springer; Bulletin Of Experimental Biology And Medicine; 174; 6; 4-2023; 745-748
dc.identifier.issn
0007-4888
dc.identifier.uri
http://hdl.handle.net/11336/233630
dc.description.abstract
In male Wistar rats, coronary occlusion (45 min) and reperfusion (120 min) were modeled. Selective δ2-opioid receptor agonist (deltorphin II, 0.12 mg/kg) was administered intravenously 5 min before reperfusion; NO synthase inhibitor (L-NAME, 10 mg/kg), MPT pore blocker (atractyloside, 5 mg/kg), and protein kinase A inhibitor (H-89, 10 μg/kg) were administered intravenously 10 min before reperfusion. Deltorphin II administered before reperfusion led to a 2-fold decrease in the infarct size. The infarct-limiting effect of deltorphin II was associated with blockade of MPT pore. Protein kinase A and NO synthase were not involved in the cardioprotective effect of deltorphin II.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEART
dc.subject
ISCHEMIA/REPERFUSION
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MPT PORE
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OPIOID RECEPTORS
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PROTEIN KINASE A
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Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The role of no synthase, MPT pore, and protein kinase a in the cardioprotective effect of the opioid receptor agonist deltorphin II
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-13T14:27:03Z
dc.identifier.eissn
1573-8221
dc.journal.volume
174
dc.journal.number
6
dc.journal.pagination
745-748
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Mukhomedzyanov, A. V.. Russian Academy Of Sciences. Tomsk National Research Medical Center. Cardiology Research Institute; Rusia
dc.description.fil
Fil: Popov, S. V.. Russian Academy Of Sciences. Tomsk National Research Medical Center. Cardiology Research Institute; Rusia
dc.description.fil
Fil: Maslov, L. N.. Russian Academy Of Sciences. Tomsk National Research Medical Center. Cardiology Research Institute; Rusia
dc.description.fil
Fil: Azev, V. N.. Russian Academy Of Sciences. Shemyakin-ovchinnikov Institute Of Bioorganic Chemistry; Rusia
dc.description.fil
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Bulletin Of Experimental Biology And Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10517-023-05784-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10517-023-05784-4
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