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dc.contributor.author
Freitas, Ítalo Nascimento
dc.contributor.author
Dourado, Amanda Vieira
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Araújo, Amanda Pereira da Costa
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Silva de Souza, Sindoval
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Luz, Thiarlen Marinho da
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Guimarães, Abraão Tiago Batista
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Gomes, Alex Rodrigues
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Islam, Abu Reza Md. Towfiqul
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Rahman, Md. Mostafizur
dc.contributor.author
Arias, Andres Hugo
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Mubarak Ali, Davoodbasha
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Ragavendran, Chinnasamy
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Kamaraj, Chinnaperumal
dc.contributor.author
Malafaia, Guilherme
dc.date.available
2024-04-19T11:20:12Z
dc.date.issued
2022-02-01
dc.identifier.citation
Freitas, Ítalo Nascimento; Dourado, Amanda Vieira; Araújo, Amanda Pereira da Costa; Silva de Souza, Sindoval; Luz, Thiarlen Marinho da; et al.; Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity; Elsevier Science; Science of the Total Environment; 858; 159838; 1-2-2022; 1-13
dc.identifier.issn
1879-1026
dc.identifier.uri
http://hdl.handle.net/11336/233519
dc.description.abstract
The dispersion of SARS-CoV-2 in aquatic environments via the discharge of domestic and hospital sewage has been confirmed in different locations. Thus, we aimed to evaluate the possible impacts of zebrafish (Danio rerio) exposure to SARS-CoV-2 peptide fragments (PSPD-2001, 2002, and 2003) alone and combined with a mix of emerging pollutants. Our data did not reveal the induction of behavioral, biometric, or mutagenic changes. But we noticed an organ-dependent biochemical response. While nitric oxide and malondialdehyde production in the brain, gills, and muscle did not differ between groups, superoxide dismutase activity was reduced in the “PSPD”, “Mix”, and “Mix+PSPD” groups. An increase in catalase activity and a reduction in DPPH radical scavenging activity were observed in the brains of animals exposed to the treatments. However, the “Mix+PSPD” group had a higher IBRv2 value, with NO levels (brain), the reduction of acetylcholinesterase activity (muscles), and the DPPH radical scavenging activity (brain and muscles), the most discriminant factors for this group. The principal component analysis (PCA) and hierarchical clustering analysis indicated a clear separation of the “Mix+PSPD” group from the others. Thus, we conclude that exposure to viral fragments, associated with the mix of pollutants, induced more significant toxicity in zebrafish adults than in others.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOMARKERS
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COVID-19
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DANIO RERIO
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FRESHWATER ECOSYSTEMS
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NON-TARGET ORGANISMS
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NOVEL CORONAVIRUS
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Oceanografía, Hidrología, Recursos Hídricos
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dc.subject.classification
Ciencias de la Tierra y relacionadas con el Medio Ambiente
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-04-17T13:08:22Z
dc.journal.volume
858
dc.journal.number
159838
dc.journal.pagination
1-13
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Freitas, Ítalo Nascimento. Goiano Federal Institute; Brasil. Universidade Federal de Uberlândia; Brasil
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Fil: Dourado, Amanda Vieira. Goiano Federal Institute; Brasil
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Fil: Araújo, Amanda Pereira da Costa. Universidade Federal de Goiás; Brasil
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Fil: Silva de Souza, Sindoval. Universidade Federal de Goiás; Brasil
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Fil: Luz, Thiarlen Marinho da. Goiano Federal Institute; Brasil
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Fil: Guimarães, Abraão Tiago Batista. Goiano Federal Institute; Brasil
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Fil: Gomes, Alex Rodrigues. Universidade Federal de Uberlândia; Brasil. Goiano Federal Institute; Brasil
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Fil: Islam, Abu Reza Md. Towfiqul. Begum Rokeya University; Bangladesh
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Fil: Rahman, Md. Mostafizur. Jahangirnagar University; Bangladesh
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Fil: Arias, Andres Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina
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Fil: Mubarak Ali, Davoodbasha. Universiti Teknologi Brunei; Brunéi
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Fil: Ragavendran, Chinnasamy. Saveetha Dental College And Hospitals; India
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Fil: Kamaraj, Chinnaperumal. Srm Institute Of Science And Technology; India
dc.description.fil
Fil: Malafaia, Guilherme. Universidade Federal de Goiás; Brasil. Goiano Federal Institute; Brasil. Universidade Federal de Uberlândia; Brasil
dc.journal.title
Science of the Total Environment
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.scitotenv.2022.159838
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0048969722069388
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