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dc.contributor.author
Izzo, Franco
dc.contributor.author
Landau, Dan Avi
dc.date.available
2017-08-30T20:17:27Z
dc.date.issued
2016-05
dc.identifier.citation
Izzo, Franco; Landau, Dan Avi; Genetic and epigenetic determinants of B-cell lymphoma evolution; Lippincott Williams; Current Opinion in Hematology; 23; 4; 5-2016; 392-401
dc.identifier.issn
1065-6251
dc.identifier.uri
http://hdl.handle.net/11336/23340
dc.description.abstract
The success of targeted therapies fostered the development of increasingly specific and effective therapeutics for B-cell malignancies. However, cancer plasticity facilitates disease relapse, whereby intratumoral heterogeneity fuels tumor evolution into a more aggressive and resistant form. Understanding cancer heterogeneity and the evolutionary processes underlying disease relapse is key for overcoming this limitation of current treatment strategies. In the present review, we delineate the current understanding of cancer evolution and the advances in both genetic and epigenetic fields, with a focus on non-Hodgkin B-cell lymphomas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
B Cell Lymphoma
dc.subject
Clonal Evolution
dc.subject
Cancer Evolution
dc.subject
Genetic Heterogeneity
dc.subject
Chronic Lymphocytic Leukemia
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Patología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic and epigenetic determinants of B-cell lymphoma evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-24T15:32:24Z
dc.identifier.eissn
1531-7048
dc.journal.volume
23
dc.journal.number
4
dc.journal.pagination
392-401
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Izzo, Franco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. New York Genome Center; Estados Unidos. Weill Cornell Medicine. Sandra and Edward Meyer Cancer Center; Estados Unidos
dc.description.fil
Fil: Landau, Dan Avi. Weill Cornell Medicine. Sandra and Edward Meyer Cancer Center; Estados Unidos. New York Genome Center; Estados Unidos
dc.journal.title
Current Opinion in Hematology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/co-hematology/pages/articleviewer.aspx?year=2016&issue=07000&article=00015&type=abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MOH.0000000000000258
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/27135978
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