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Artículo

Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity

Quinteros, Melisa de los ÁngelesIcon ; Cano Aristizábal, VivianaIcon ; Dalmasso, Pablo RobertoIcon ; Paraje, María GabrielaIcon ; Páez, Paulina LauraIcon
Fecha de publicación: 08/2016
Editorial: Elsevier
Revista: Toxicology in Vitro
ISSN: 0887-2333
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Oxidative stress is a condition caused by the high intracellular concentrations of reactive oxygen species (ROS) that includes superoxide anion radicals, hydroxyl radicals and hydrogen peroxide. Nanoparticles could cause rapid generation of free radicals by redox reactions. ROS can react directly with membrane lipids, proteins and DNA and are normally scavenged by antioxidants that are capable of neutralizing; however, elevated concentrations of ROS in bacterial cells can result in oxidative stress. The aim of this work was contribute to the knowledge of action mechanism of silver nanoparticles (Ag-NPs) and their relation to the generation of oxidative stress in bacteria. We demonstrated that Ag-NPs generated oxidative stress in Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa mediated by the increment of ROS and this increase correlated with a better antimicrobial activity. On the other hand, we showed that the oxidative stress caused by the Ag-NPs biosynthesized was associated to a variation in the level of reactive nitrogen intermediates (RNI). Oxidative stress in bacteria can result from disruption of the electronic transport chain due to the high affinity of Ag-NPs for the cell membrane. The formation of ROS and RNI by Ag-NPs may also be considered to explain the bacterial death.
Palabras clave: Antimicrobial Activity , Bacteria , Biosynthesis , Oxidative Stress , Silver Nanoparticles
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/23335
DOI: http://dx.doi.org/10.1016/j.tiv.2016.08.007
URL: http://www.sciencedirect.com/science/article/pii/S0887233316301564
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Quinteros, Melisa de los Ángeles; Cano Aristizábal, Viviana; Dalmasso, Pablo Roberto; Paraje, María Gabriela; Páez, Paulina Laura; Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity; Elsevier; Toxicology in Vitro; 36; 8-2016; 216-223
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