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dc.contributor.author
Cadet, Jean Lud
dc.contributor.author
Bisagno, Veronica
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Milroy, Christopher Mark
dc.date.available
2015-10-05T19:27:12Z
dc.date.issued
2013-11-29
dc.identifier.citation
Cadet, Jean Lud; Bisagno, Veronica; Milroy, Christopher Mark; Neuropathology of substance use disorders; Springer; Acta Neuropathologica; 127; 1; 29-11-2013; 91-107
dc.identifier.issn
0001-6322
dc.identifier.uri
http://hdl.handle.net/11336/2326
dc.description.abstract
Addictions to licit and illicit drugs are chronic relapsing brain disorders that affect circuits that regulate reward, motivation, memory, and decision-making. Drug-induced pathological changes in these brain regions are associated with characteristic enduring behaviors that continue despite adverse biopsychosocial consequences. Repeated exposure to these substances leads to egocentric behaviors that focus on obtaining the drug by any means and on taking the drug under adverse psychosocial and medical conditions. Addiction also includes craving for the substances and, in some cases, involvement in risky behaviors that can cause death. These patterns of behaviors are associated with specific cognitive disturbances and neuroimaging evidence for brain dysfunctions in a diverse population of drug addicts. Postmortem studies have also revealed significant biochemical and/or structural abnormalities in some addicted individuals. The present review provides a summary of the evidence that has accumulated over the past few years to implicate brain dysfunctions in the varied manifestations of drug addiction. We thus review data on cerebrovascular alterations, brain structural abnormalities, and postmortem studies of patients who abuse cannabis, cocaine, amphetamines, heroin, and “bath salts”. We also discuss potential molecular, biochemical, and cellular bases for the varied clinical presentations of these patients. Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations.
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application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cannabis
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Cocaine
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Methamphetamine
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Mdma
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Heroin
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Cathinones
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Bath Salts
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Dopamine
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Toxicitystriatum
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Frontal Cortex
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Hippocampus
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Nucleus Accumbens
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Reward Mechanisms
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Drogadicción
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neuropathology of substance use disorders
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1432-0533
dc.journal.volume
127
dc.journal.number
1
dc.journal.pagination
91-107
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Cadet, Jean Lud. Molecular Neuropsychiatry Research Branch; Estados Unidos
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Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
dc.description.fil
Fil: Milroy, Christopher Mark. The Ottawa Hospital; Canadá
dc.journal.title
Acta Neuropathologica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00401-013-1221-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00401-013-1221-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453825/
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