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dc.contributor.author
Odetti, Lucia Magdalena
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dc.contributor.author
Paravani, Enrique Valentin
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dc.contributor.author
Simoniello, Maria Fernanda
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dc.contributor.author
Poletta, Gisela Laura
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dc.date.available
2024-04-08T13:58:45Z
dc.date.issued
2022
dc.identifier.citation
Odetti, Lucia Magdalena; Paravani, Enrique Valentin; Simoniello, Maria Fernanda; Poletta, Gisela Laura; The Role of Superoxide Dismutase in Reptiles under Toxicity Contexts; Nova Science Publishers; 20; 2022; 167-190
dc.identifier.isbn
979-8-88697-199-6
dc.identifier.uri
http://hdl.handle.net/11336/232373
dc.description.abstract
Reptiles are important models in evolutionary history and several species are of great ecological, sociological and commercial importance. They are transcendental in natural ecosystems, as prey, predators, herbivores, seed dispersers and as bioindicators of environmental health. In recentdecades, the role of environmental pollution as a possible reason for the decline of reptile populations has prompted researchers to evaluate the effects of pesticides on these vertebrate groups. Given the expansion of agricultural frontiers, many reptile populations live now in habitat subjected to high pollution pressure, and due to their biological characteristics, they may be exposed to pollutants at all stages of their lives. As a consequence, they appear worldwide as excellent model species of environmental contamination by different xenobiotics. Environmental pollutants are known to induce oxidative damage to biomolecules, such as proteins, lipids, and nucleic acids, due to the production of reactive oxygen species (ROS). ROS are highly reactiveand potentially deleterious to biological systems. To minimize the effects that ROS can generate, aerobic organisms have developed enzymatic and non-enzymatic antioxidant defenses. Enzymatic defenses, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase(GPx), protect the organism by directly eliminating superoxide radicals and hydrogen peroxide, converting them into less reactive species. Oxidative stress occurs as a result of an imbalance between ROS and antioxidant mechanisms, leading to a variety of physiological and biochemical changes that cause cell deterioration and death. This occurs due to an excessive accumulation of ROS, decrease in antioxidant enzymes, or both. Specifically, SOD is the first line of defense and themost powerful antioxidant in the cell. It catalyzes the dismutation of superoxide anion (O2?-) into hydrogen peroxide (H2O2) and oxygen (O2), making potentially harmful O2?- less dangerous. Four isoforms of SOD enzyme have been described, according to their metallic cofactor; Fe- SOD, Mn-SOD, Ni-SOD and Cu/Zn-SOD, which have distinct subcellular locations. SOD has demonstrated to be sensible to environmental contamination and several studies carried out in reptiles have shown that exposure to xenobiotics produces inhibition or overproduction of SOD or altered sod gene expression in different tissues. Considering the importance of reptiles in the ecosystem and theaction of SOD against environmental pollutants, the aim of this chapter is to present the current knowledge into the structure-activity relationship and mechanism of action of SOD in a reptile species, and its importance as a biomarker for environmental contamination in sentinel species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
reptiles
dc.subject
sentinel species
dc.subject
environmental pollution
dc.subject
oxidative strees
dc.subject
biomarkers
dc.subject.classification
Otros Tópicos Biológicos
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The Role of Superoxide Dismutase in Reptiles under Toxicity Contexts
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2024-04-08T12:56:51Z
dc.journal.volume
20
dc.journal.pagination
167-190
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Odetti, Lucia Magdalena. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Paravani, Enrique Valentin. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina
dc.description.fil
Fil: Poletta, Gisela Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/advances-in-animal-science-and-zoology-volume-20/
dc.conicet.paginas
238
dc.source.titulo
Advances in Animal Science and Zoology
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