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dc.contributor.author
Renna, Nicolas Federico
dc.contributor.author
de Las Heras, Maria Evangelina
dc.contributor.author
Miatello, Roberto Miguel
dc.date.available
2015-10-05T16:30:24Z
dc.date.issued
2013-07
dc.identifier.citation
Renna, Nicolas Federico; de Las Heras, Maria Evangelina; Miatello, Roberto Miguel; Pathophysiology of vascular remodeling in hypertension; Hindawi Publishing Corporation; International Journal of Hypertension; 2013; 7-2013; 1-7
dc.identifier.issn
2090-0384
dc.identifier.uri
http://hdl.handle.net/11336/2321
dc.description.abstract
Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov’s contribution. We then move to some basic concepts on the biomechanics of blood vessels and explain the definitions proposed by Mulvany for specific forms of remodeling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodeled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodeling is described, again with emphasis on human data. Some details are given on the three mechanisms to date which point to remodeling resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Vascular Remodeling
dc.subject
Metabolic Syndrome
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Hypertension
dc.subject
Pathophysiology
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Fisiología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Pathophysiology of vascular remodeling in hypertension
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
2013
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva Yoork
dc.description.fil
Fil: Renna, Nicolas Federico. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Patológica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina;
dc.description.fil
Fil: de Las Heras, Maria Evangelina. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiologia; España;
dc.description.fil
Fil: Miatello, Roberto Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Patológica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina;
dc.journal.title
International Journal of Hypertension
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/808353
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ijhy/2013/808353/
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