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dc.contributor.author
Caraballo, Roberto Horacio
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dc.contributor.author
Reyes Valenzuela, Gabriela
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dc.contributor.author
Fortini, Sebastian
dc.contributor.author
Espeche, Alberto
dc.contributor.author
Gamboni, Beatriz
dc.contributor.author
Silva, Walter
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dc.contributor.author
Semprino, Marcos
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Fasulo, Lorena
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Chacón, Santiago
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Gallo, Adolfo
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Galicchio, Santiago
dc.contributor.author
Cachia, Pedro
dc.date.available
2024-04-05T11:55:47Z
dc.date.issued
2023-05
dc.identifier.citation
Caraballo, Roberto Horacio; Reyes Valenzuela, Gabriela; Fortini, Sebastian; Espeche, Alberto; Gamboni, Beatriz; et al.; Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures; Elsevier; Epilepsy and Behavior; 143; 5-2023; 1-8
dc.identifier.uri
http://hdl.handle.net/11336/232070
dc.description.abstract
Purpose: This multicenter study aimed to evaluate the efficacy and tolerability of add-on cannabidiol (CBD) in treatment-resistant patients with epilepsy with myoclonic-atonic seizures (EMAtS) (n = 22) and Sturge Weber syndrome (SWS) with myoclonic-atonic seizures (n = 4). Methods: Patients who met the diagnostic criteria of treatment-resistant EMAtS or SWS with myoclonic-atonic seizures were included. Cannabidiol was added in doses ranging from 8 to 40 mg/kg/day. Efficacy was assessed by comparing seizure frequency before and after initiating CBD therapy. Neurologic examinations, brain magnetic resonance imaging, repeated prolonged electroencephalography (EEG) and/or video-EEG recordings, and neurometabolic studies were performed in all patients, and genetic investigations in 15. Results: After a mean follow-up of 19 months, 15/26 patients (57.7%) who received add-on CBD had a >50% seizure decrease; three (11.5%) became seizure-free. The remaining 11 patients (42.3%) had a 25–50% seizure reduction. Drop attacks, including myoclonic-atonic seizures and generalized tonic-clonic seizures, as well as atypical absences and nonconvulsive status epilepticus responded well to CBD. In SWS patients, focal motor seizures without consciousness impairment and focal non-motor seizures with consciousness impairment were recognized in two each; in three a 30% reduction of focal seizures was observed. Side effects were mild and did not lead to CBD discontinuation. Conclusion: This study evaluating the use of add-on CBD in children with EMAtS or SWS with myoclonic-atonic seizures found that 15/26 (57.7%) had a >50% seizure reduction with good tolerability; three (11.5%) became seizure-free.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cannabidiol
dc.subject
Drop attacks
dc.subject
Epilepsy
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Myoclonic-atonic seizures
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Sturge Weber syndrome
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Treatment-resistant
dc.subject.classification
Neurología Clínica
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-26T13:22:57Z
dc.identifier.eissn
1525-5069
dc.journal.volume
143
dc.journal.pagination
1-8
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Caraballo, Roberto Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Reyes Valenzuela, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Fortini, Sebastian. Provincia de Tucumán. Ministerio de Salud. Sistema Provincial de Salud. Hospital del Niño Jesús; Argentina
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Fil: Espeche, Alberto. Hospital Público Materno Infantil; Argentina
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Fil: Gamboni, Beatriz. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti;
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Fil: Silva, Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
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Fil: Semprino, Marcos. Clínica San Lucas; Argentina
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Fil: Fasulo, Lorena. Clínica San Lucas; Argentina
dc.description.fil
Fil: Chacón, Santiago. Clínica Neurología Infantil Ceni; Argentina
dc.description.fil
Fil: Gallo, Adolfo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Galicchio, Santiago. Hospital de Niños Victor J Vilela de Rosario; Argentina
dc.description.fil
Fil: Cachia, Pedro. Hospital de Niños Victor J Vilela de Rosario; Argentina
dc.journal.title
Epilepsy and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1525505023001646
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.yebeh.2023.109245
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