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dc.contributor.author
Armeno, Marisa
dc.contributor.author
Galligaris, Silvana
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Gagiulo, Daniela
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Cresta, Araceli
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Vaccarezza, Maria Magdalena
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Diez, Cecilia Griselda
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Alberti, Maria Julia
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Viollaz, Rocio
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Vilavedra, Francisco
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Caraballo, Roberto Horacio
dc.date.available
2024-03-27T11:58:05Z
dc.date.issued
2024-02
dc.identifier.citation
Armeno, Marisa; Galligaris, Silvana; Gagiulo, Daniela; Cresta, Araceli; Vaccarezza, Maria Magdalena; et al.; Use of ketogenic dietary therapy for drug-resistant epilepsy in early infancy; John Wiley & Sons; Epilepsia Open; 9; 1; 2-2024; 138-149
dc.identifier.issn
2470-9239
dc.identifier.uri
http://hdl.handle.net/11336/231653
dc.description.abstract
Objective: There is growing evidence that ketogenic dietary therapy (KDT) can be safely and efficiently used in young children, but little evidence exists on its use in newborns. Developmental and epileptic encephalopathies starting in the neonatal period or early infancy usually present a poor prognosis. The aim of this study was to evaluate effectiveness, safety, and survival of infants younger than 3 months of age with drug-resistant epilepsy in whom KDT was used.Methods: A retrospective study was conducted to evaluate neonates and infants younger than 3 months who started KDT for drug-resistant developmental and epileptic encephalopathies at three referral centers. Data were collected on demographic features, time of epilepsy onset, epilepsy syndrome, seizure type, seizure frequency at diet onset, etiology, details regarding diet initiation, type of ketogenic formula, breastfeeding, route of administration, blood ketones, growth, length of NICU stay, and survival.Results: Nineteen infants younger than 12 weeks of life who received KDT with a minimum follow-up of 1 month were included; 13 had early-infantile developmental and epileptic encephalopathy, four epilepsy of infancy with migrating focal seizures, and two focal epilepsy. A >50% response was observed in 73.7% at 1 month on the diet; 37% achieved a > 75% seizure reduction, and 10.5% became seizure free. At 3 months, a >50% decrease in seizure frequency was observed in 72.2%; 15.8% had a >75% reduction; 21% became seizure free. Overall survival was 76% at 1 year on diet. Incidence of acute and late adverse effects was low and most adverse effects were asymptomatic and manageable.Significance: Our experience suggests that KDT is safe and effective in newborns and very young infants; however, further studies on the management of the diet in this vulnerable age group are necessary.
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application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Developmental and epileptic encephalopathies
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Drug-resistant
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Early infancy
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Ketogenic diet therapy
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Neurología Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Use of ketogenic dietary therapy for drug-resistant epilepsy in early infancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-26T13:34:48Z
dc.journal.volume
9
dc.journal.number
1
dc.journal.pagination
138-149
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Armeno, Marisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Galligaris, Silvana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Gagiulo, Daniela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Cresta, Araceli. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Vaccarezza, Maria Magdalena. Hospital Italiano; Argentina
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Fil: Diez, Cecilia Griselda. Hospital Italiano; Argentina
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Fil: Alberti, Maria Julia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
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Fil: Viollaz, Rocio. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
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Fil: Vilavedra, Francisco. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
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Fil: Caraballo, Roberto Horacio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Epilepsia Open
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/epi4.12836
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