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dc.contributor.author
Lobos de Ponga, Jacquelina Claudia
dc.contributor.author
Piña, Juliana
dc.contributor.author
Cotabarren, Ivana María
dc.date.available
2024-03-22T11:22:44Z
dc.date.issued
2023-09-15
dc.identifier.citation
Lobos de Ponga, Jacquelina Claudia; Piña, Juliana; Cotabarren, Ivana María; Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory; Multidisciplinary Digital Publishing Institute; Powders; 2; 3; 15-9-2023; 639-658
dc.identifier.issn
2674-0516
dc.identifier.uri
http://hdl.handle.net/11336/231268
dc.description.abstract
The understanding of granule growth mechanisms and the effects of formulation and operating conditions over product quality and process performance in fluidized bed co-melt granulation is nowadays of great interest. In this sense, this work systematically studies the combined effects of binder content (WPEG) and fluidization air flowrate (FA) and temperature (TA) on granules’ quality and process-related variables (product mass (MP), elutriated fines (Mf), mass stuck on walls (MW)) by using a Box–Behnken-type design of experiments (DoE), as it is a statistical tool suggested by the Quality by Design (QbD) initiative. It was found that the granules’ size and powder flowability are significantly affected by WPEG (higher WPEG, higher granule size and better flowability). Interestingly, TA is the process variable that significantly affects MP, enhancing process performance at high temperature values. Regarding FA, it significantly affects d10, promoting the formation of small particles due to breakage at high flowrates and the presence of non-elutriated powder at low flowrates. As a consequence, intermediate FA is the optimum for obtaining higher MP. Regarding regime map studies, most runs experienced a rapid growth regime, which is in accordance with the granules’ high pore saturation. This result agrees with the observed high increment in particle size and the morphology of the final granules, allowing researchers to validate and extend existing previous maps.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
FLUIDIZED-BED GRANULATION
dc.subject
CO-MELT
dc.subject
REGIME MAP
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BOX-BEHNEKEN
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LACTOSE
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POLYEHTYLENE GLICOL
dc.subject.classification
Ingeniería de Procesos Químicos
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Ingeniería Química
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-08T15:18:13Z
dc.journal.volume
2
dc.journal.number
3
dc.journal.pagination
639-658
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Lobos de Ponga, Jacquelina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
dc.description.fil
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
dc.description.fil
Fil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
dc.journal.title
Powders
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2674-0516/2/3/40
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/powders2030040
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