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dc.contributor.author
Deng, Bin
dc.contributor.author
Vanagas, Laura
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dc.contributor.author
Alonso, Andrés Mariano
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dc.contributor.author
Ángel, Sergio Oscar
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dc.date.available
2024-03-20T15:04:11Z
dc.date.issued
2024-01
dc.identifier.citation
Deng, Bin; Vanagas, Laura; Alonso, Andrés Mariano; Ángel, Sergio Oscar; Proteomics Applications in Toxoplasma gondii: Unveiling the Host-parasite Interactions and Therapeutic Target Discovery; MDPI; Pathogens; 13; 1; 1-2024; 1-29
dc.identifier.issn
2076-0817
dc.identifier.uri
http://hdl.handle.net/11336/231076
dc.description.abstract
Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses significant risks, leading to severe complications in immunocompromised individuals and potentially affecting the fetus through congenital transmission. A comprehensive understanding of the intricate molecular interactions between T. gondii and its host is pivotal for the development of effective therapeutic strategies. This review emphasizes the crucial role of proteomics in T. gondii research, with a specific focus on host-parasite interactions, post-translational modifications (PTMs), PTM crosstalk, and ongoing efforts in drug discovery. Additionally, we provide an overview of recent advancements in proteomics techniques, encompassing interactome sample preparation methods such as BioID (BirA*-mediated proximity-dependent biotin identification), APEX (ascorbate peroxidase-mediated proximity labeling), and Y2H (yeast two-hybrid), as well as various proteomics approaches, including single-cell analysis, DIA (data-independent acquisition), targeted, top-down, and plasma proteomics. Furthermore, we discuss bioinformatics and the integration of proteomics with other omics technologies, highlighting its potential in unraveling the intricate mechanisms of T. gondii pathogenesis and identifying novel therapeutic targets.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Toxoplasma
dc.subject
Proteomica
dc.subject
terapia
dc.subject
bioinformatica
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Proteomics Applications in Toxoplasma gondii: Unveiling the Host-parasite Interactions and Therapeutic Target Discovery
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-19T14:17:50Z
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
1-29
dc.journal.pais
Suiza
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dc.description.fil
Fil: Deng, Bin. University Of Vermont.; Estados Unidos
dc.description.fil
Fil: Vanagas, Laura. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina
dc.description.fil
Fil: Alonso, Andrés Mariano. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina
dc.description.fil
Fil: Ángel, Sergio Oscar. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina
dc.journal.title
Pathogens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-0817/13/1/33
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/pathogens13010033
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