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Artículo

Bioenergetic changes in response to sperm capacitation and two-way metabolic compensation in a new murine model

Tourmente, MaximilianoIcon ; Sansegundo, Ester; Rial, Eduardo; Roldan, Eduardo R. S.
Fecha de publicación: 01/2023
Editorial: Springer
Revista: Cellular and Molecular Life Sciences
ISSN: 1420-682X
e-ISSN: 1420-9071
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología; Biología Reproductiva; Bioquímica y Biología Molecular

Resumen

The acquisition of fertilizing ability by mammalian spermatozoa, known as “capacitation,” includes processes that depend on particular metabolic pathways. This has led to the hypothesis that ATP demands might differ between capacitated and non-capacitated cells. Mouse sperm can produce ATP via OXPHOS and aerobic glycolysis, an advantageous characteristic considering that these cells have to function in the complex and variable environment of the female reproductive tract. Nonetheless, despite evidence showing that both metabolic pathways play a role in events associated with mouse sperm capacitation, there is contradictory evidence regarding changes promoted by capacitation in this species. In addition, the vast majority of studies regarding murine sperm metabolism use Mus musculus laboratory strains as model, thus neglecting the wide diversity of sperm traits of other species of Mus. Focus on closely related species with distinct evolutionary histories, which may be the result of different selective pressures, could shed light on diversity of metabolic processes. Here, we analyzed variations in sperm bioenergetics associated with capacitation in spermatozoa of the steppe mouse, Mus spicilegus, a species with high sperm performance. Furthermore, we compared sperm metabolic traits of this species with similar traits previously characterized in M. musculus. We found that the metabolism of M. spicilegus sperm responded to capacitation in a manner similar to that of M. musculus sperm. However, M. spicilegus sperm showed distinct metabolic features, including the ability to perform cross-pathway metabolic compensation in response to either respiratory or glycolytic inhibition, thus revealing a delicate fine-tuning of its metabolic capacities.
Palabras clave: CAPACITATION , METABOLIC COMPENSATION , METABOLISM , MUS SPICILEGUS , SPERM
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/230576
URL: https://link.springer.com/article/10.1007/s00018-022-04652-0
DOI: http://dx.doi.org/10.1007/s00018-022-04652-0
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Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Citación
Tourmente, Maximiliano; Sansegundo, Ester; Rial, Eduardo; Roldan, Eduardo R. S.; Bioenergetic changes in response to sperm capacitation and two-way metabolic compensation in a new murine model; Springer; Cellular and Molecular Life Sciences; 80; 1; 1-2023; 1-20
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