Artículo
Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
Gonzales Moreno, Candelaria
; Fernandez Hubeid, Lucia Eugenia
; Holgado, Andrea; Virgolini, Miriam Beatriz
Fecha de publicación:
03/2023
Editorial:
CalTech Library
Revista:
microPublication Biology
e-ISSN:
2578-9430
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Exposure to the herbicide paraquat (PQ; 1,1′-dimethyl-4,4′-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in Caenorhabditis elegans after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.
Palabras clave:
C ELEGANS
,
PARAQUAT
,
N ACETYL CYSTEINE
,
MORTALITY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Citación
Gonzales Moreno, Candelaria; Fernandez Hubeid, Lucia Eugenia; Holgado, Andrea; Virgolini, Miriam Beatriz; Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans; CalTech Library; microPublication Biology; 2023; 3-2023; 1-6
Compartir
Altmétricas