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dc.contributor.author
Charif, Santiago Elías
dc.contributor.author
Inserra, Pablo Ignacio Felipe
dc.contributor.author
Di Giorgio, Noelia Paula
dc.contributor.author
Schmidt, Alejandro Raúl
dc.contributor.author
Lux, Victoria Adela R.
dc.contributor.author
Vitullo, Alfredo Daniel
dc.contributor.author
Dorfman, Verónica Berta
dc.date.available
2017-08-25T20:42:56Z
dc.date.issued
2016-01-01
dc.identifier.citation
Charif, Santiago Elías; Inserra, Pablo Ignacio Felipe; Di Giorgio, Noelia Paula; Schmidt, Alejandro Raúl; Lux, Victoria Adela R.; et al.; Sequence analysis, tissue distribution and molecular physiology of the GnRH preprogonadotrophin in the South American plains vizcacha (Lagostomus maximus); Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 232; 1-1-2016; 174-184
dc.identifier.issn
0016-6480
dc.identifier.uri
http://hdl.handle.net/11336/23047
dc.description.abstract
Gonadotropin-releasing hormone (GnRH) is the regulator of the hypothalamic-hypophyseal-gonadal (HHG) axis. GnRH and GAP (GnRH-associated protein) are both encoded by a single preprohormone. Different variants of GnRH have been described. In most mammals, GnRH is secreted in a pulsatile manner that stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The South-American plains vizcacha, Lagostomus maximus, is a rodent with peculiar reproductive features including natural poly-ovulation up to 800 oocytes per estrous cycle, pre-ovulatory follicle formation throughout pregnancy and an ovulatory process which takes place at mid-gestation and adds a considerable number of secondary corpora lutea. Such features should occur under a special modulation of the HHG axis, guided by GnRH. The aim of this study was to sequence hypothalamic GnRH preprogonadotrophin mRNA in the vizcacha, to compare it with evolutionarily related species and to identify its expression, distribution and pulsatile pattern of secretion. The GnRH1variant was detected and showed the highest homology with that of chinchilla, its closest evolutionarily related species. Two isoforms of transcripts were identified, carrying the same coding sequence, but different 5´ untranslated regions. This suggests a sensitive equilibrium between RNA stability and translational efficiency. A predominant hypothalamic localization and a pulsatile secretion pattern of one pulse of GnRH every hour were found. The lower homology found for GAP, also among evolutionarily related species, depicts a potentially different bioactivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Plains Vizcacha
dc.subject
Gnrh
dc.subject
Pregnancy
dc.subject
South America
dc.subject
Gonadotrophin - Releasing Hormonne
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Sequence analysis, tissue distribution and molecular physiology of the GnRH preprogonadotrophin in the South American plains vizcacha (Lagostomus maximus)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-09T16:57:18Z
dc.identifier.eissn
1095-6840
dc.journal.volume
232
dc.journal.pagination
174-184
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Charif, Santiago Elías. Universidad Maimonides. Area de Invest.biomédicas y Biotecnologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Inserra, Pablo Ignacio Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimonides. Area de Invest.biomédicas y Biotecnologicas; Argentina
dc.description.fil
Fil: Di Giorgio, Noelia Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Schmidt, Alejandro Raúl. Universidad Maimonides. Area de Invest.biomédicas y Biotecnologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Vitullo, Alfredo Daniel. Universidad Maimonides. Area de Invest.biomédicas y Biotecnologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dorfman, Verónica Berta. Universidad Maimonides. Area de Invest.biomédicas y Biotecnologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
General and Comparative Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648015300472
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ygcen.2015.12.012
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