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dc.contributor.author
Castillo, Victor Alejandro
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dc.contributor.author
Pessina, P.
dc.contributor.author
Blatter, M. F.
dc.contributor.author
Miceli, Diego Daniel
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dc.contributor.author
Soler Arias, E.
dc.contributor.author
Vidal, P.
dc.date.available
2017-08-25T20:34:22Z
dc.date.issued
2016-01-20
dc.identifier.citation
Castillo, Victor Alejandro; Pessina, P.; Blatter, M. F.; Miceli, Diego Daniel; Soler Arias, E.; et al.; Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome; University of Tripoli; Open Veterinary Journal; 6; 1; 20-1-2016; 6-14
dc.identifier.issn
2226-4485
dc.identifier.uri
http://hdl.handle.net/11336/23041
dc.description.abstract
The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatmentof thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogsto receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed intoeither group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cyclesor group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrencewas significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did notdetect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratioof recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The typeof carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival timethan compact carcinomas. The interaction among treatment and type was significant, but survival time in follicularcarcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greaterthan GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that theuse of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the timeto tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinomainteracted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having aworse prognosis than differentiated carcinomas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
University of Tripoli
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Thyroid Carcinoma
dc.subject
Retinoic Acid
dc.subject
Dogs
dc.subject
Post-Surgical Treatment
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-09T16:57:03Z
dc.identifier.eissn
2218-6050
dc.journal.volume
6
dc.journal.number
1
dc.journal.pagination
6-14
dc.journal.pais
Libia
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dc.journal.ciudad
Tripoli
dc.description.fil
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Pessina, P.. Universidad de la República; Uruguay
dc.description.fil
Fil: Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Soler Arias, E.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Vidal, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
Open Veterinary Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.openveterinaryjournal.com/volume6no12016.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.4314/ovj.v6i1.2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744371/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/26862515
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