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dc.contributor.author
Aschner, Michael
dc.contributor.author
Skalny, Anatoly V.
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Santamaria, Abel
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Buha Djordjevic, Aleksandra
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Tizabi, Yousef
dc.contributor.author
Jiang, Yueming
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Lu, Rongzhu
dc.contributor.author
Virgolini, Miriam Beatriz
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dc.contributor.author
Tinkov, Alexey A.
dc.date.available
2024-03-11T11:15:21Z
dc.date.issued
2023-09
dc.identifier.citation
Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-21
dc.identifier.issn
2768-6701
dc.identifier.uri
http://hdl.handle.net/11336/229939
dc.description.abstract
Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IMR Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BRAIN
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NANOPARTICLE
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NEURODEGENERATION
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NEUROINFLAMMATION
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NEUROTOXICITY
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TITANIUM
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Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-08T14:23:56Z
dc.identifier.eissn
2768-6698
dc.journal.volume
28
dc.journal.number
9
dc.journal.pagination
1-21
dc.journal.pais
Singapur
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dc.description.fil
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
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Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
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Fil: Santamaria, Abel. Universidad Nacional Autónoma de México; México
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Fil: Buha Djordjevic, Aleksandra. University Of Belgrade; Serbia
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Fil: Tizabi, Yousef. Howard University College of Medicine; Estados Unidos
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Fil: Jiang, Yueming. Guangxi Medical University; China
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Fil: Lu, Rongzhu. Jiangsu University; China
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Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia
dc.journal.title
Frontiers in Bioscience - Landmark
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.31083/j.fbl2809204
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