Artículo
Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection
Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén
; Contigiani, Marta Silvia; Ré, Viviana Elizabeth
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
07/2013
Editorial:
Oxford University Press
Revista:
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN:
0035-9203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
Palabras clave:
Haart
,
Hiv/Hcv Coinfection
,
Response to Therapy
,
Cd4 Cell Counts
,
Viral Load
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Farias, Adrian Alejandro; Kremer, Luís Emilio; Allende, Luís; Diaz, Maria del Pilar; Pisano, María Belén; et al.; Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection; Oxford University Press; Transactions of the Royal Society of Tropical Medicine and Hygiene; 7; 1; 7-2013; 432-437
Compartir
Altmétricas