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dc.contributor.author
Parladé, Eloi
dc.contributor.author
Sanchez, Julieta Maria
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dc.contributor.author
López Laguna, Héctor
dc.contributor.author
Unzueta, Ugutz
dc.contributor.author
Villaverde, Antonio
dc.contributor.author
Vázquez, Esther
dc.date.available
2024-03-08T19:26:22Z
dc.date.issued
2023-08
dc.identifier.citation
Parladé, Eloi; Sanchez, Julieta Maria; López Laguna, Héctor; Unzueta, Ugutz; Villaverde, Antonio; et al.; Protein features instruct the secretion dynamics from metal-supported synthetic amyloids; Elsevier Science; International Journal of Biological Macromolecules; 250; 8-2023; 1-8
dc.identifier.issn
0141-8130
dc.identifier.uri
http://hdl.handle.net/11336/229907
dc.description.abstract
Hexahistidine-tagged proteins can be clustered by divalent cations into self-containing, dynamic protein depots at the microscale, which under physiological conditions leak functional protein. While such protein granules show promise in clinics as time-sustained drug delivery systems, little is known about how the nature of their components, that is, the protein and the particular cation used as cross-linker, impact on the disintegration of the material and on its secretory performance. By using four model proteins and four different cation formulations to control aggregation, we have here determined a moderate influence of the used cation and a potent impact of some protein properties on the release kinetics and on the final fraction of releasable protein. In particular, the electrostatic charge at the amino terminus and the instability and hydropathicity indexes determine the disintegration profile of the depot. These data offer clues for the fabrication of efficient and fully exploitable secretory granules that being biocompatible and chemically homogenous allow their tailored use as drug delivery platforms in biological systems.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Recombinant proteins
dc.subject
Microparticles
dc.subject
Secretory amyloids
dc.subject
Drug delivery system
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Time sustained drug release
dc.subject
Building blocks
dc.subject.classification
Nano-materiales
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Protein features instruct the secretion dynamics from metal-supported synthetic amyloids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-22T13:40:39Z
dc.identifier.eissn
1879-0003
dc.journal.volume
250
dc.journal.pagination
1-8
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Parladé, Eloi. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Sanchez, Julieta Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: López Laguna, Héctor. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Unzueta, Ugutz. Institut d'Investigació Biomèdica Sant Pau; España. Josep Carreras Leukaemia Research Institute; España
dc.description.fil
Fil: Villaverde, Antonio. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Vázquez, Esther. Universitat Autònoma de Barcelona; España
dc.journal.title
International Journal of Biological Macromolecules
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S014181302303060X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijbiomac.2023.126164
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