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dc.contributor.author
Matzkin, Maria Eugenia
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dc.contributor.author
Beguerie, Celina
dc.contributor.author
De Zuñiga, Ignacio
dc.contributor.author
Martinez, Gustavo
dc.contributor.author
Frungieri, Monica Beatriz
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dc.date.available
2024-03-08T10:34:07Z
dc.date.issued
2023-10
dc.identifier.citation
Matzkin, Maria Eugenia; Beguerie, Celina; De Zuñiga, Ignacio; Martinez, Gustavo; Frungieri, Monica Beatriz; Impact of COVID‐19 on sperm quality and the prostaglandin and polyamine systems in the seminal fluid; John Wiley & Sons; Andrology; 10-2023; 1-18
dc.identifier.issn
2047-2919
dc.identifier.uri
http://hdl.handle.net/11336/229770
dc.description.abstract
Background: The implications of SARS-CoV-2 infection on male fertility remain largely unknown. Besides their well-known pro- and anti-inflammatory actions,prostaglandins and polyamines are present in semen, where they play key roles in sperm quality.Objectives: To analyze semen parameters, oxidative profile and the seminal fluid prostaglandin and polyamine systems in samples collected from individuals without coronavirus disease 2019 diagnosis andmen who recovered from coronavirus disease 2019.Materials and methods: This study compared semen collected from men without positive coronavirus disease 2019 diagnosis with samples obtained from individuals 1–6 months and 7–30 months post SARS-CoV-2 infection. Semen parameters, thiobarbituric acid reactive substances, cyclooxygenase 2 expression by fluorescence immunocytochemistry and immunoblotting, prostaglandin levels by enzyme immunoassay, ornithine decarboxylase activity by a radioactive assay, and polyamine and acetylated polyamine levels by thin-layer chromatography were assessed.Results: In both groups of semen samples from coronavirus disease 2019 recovered men, sperm vitality, total and progressive sperm motility, and putrescine levels were significantly decreased when compared with samples from the uninfected group. In contrast, lipid peroxidation, leukocyte-associated cyclooxygenase 2 expression, and prostaglandin D2 levels were higher in semen from coronavirus disease 2019 recovered men than in samples from uninfected individuals. While sperm concentration and morphology, ornithine decarboxylase activity, and N-acetylputrescine levels were statistically diminished in semen obtained up to 6 months after coronavirus disease 2019 recovery, these parameters remained unchanged when samples were collected 7–30 months after coronavirus disease 2019 recovery. Coronavirus disease 2019 vaccination did not show negative effects on any of the parameters evaluated.Discussion and conclusion: Our work provides insights into the detrimental impact of coronavirus disease 2019 on several sperm parameters, in some cases, even more than a year after SARS-CoV-2 infection, which would be accompanied by alterations in the seminal fluid prostaglandin and polyamine profiles. Therefore, future treatments targeting the prostaglandin and polyamine pathways in coronavirus disease 2019 recoveredmen could lead to a successful reinstatement of semen parameters.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COVID-19
dc.subject
POLYAMINES
dc.subject
PROSTAGLANDINS
dc.subject
SARS-COV-2
dc.subject
SEMEN
dc.subject
SPERMATOZOA
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Impact of COVID‐19 on sperm quality and the prostaglandin and polyamine systems in the seminal fluid
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-22T13:21:47Z
dc.identifier.eissn
2047-2927
dc.journal.pagination
1-18
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Matzkin, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Beguerie, Celina. No especifíca;
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Fil: De Zuñiga, Ignacio. No especifíca;
dc.description.fil
Fil: Martinez, Gustavo. No especifíca;
dc.description.fil
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Andrology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/andr.13548
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/andr.13548
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