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dc.contributor.author
Bertoncini, Carlos Walter
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dc.contributor.author
Celej, Maria Soledad
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dc.date.available
2024-03-08T10:32:53Z
dc.date.issued
2011-05
dc.identifier.citation
Bertoncini, Carlos Walter; Celej, Maria Soledad; Small molecule fluorescent probes for the detection of amyloid self-assembly in vitro and in vivo; Bentham Science Publishers; Current Protein and Peptide Science; 12; 3; 5-2011; 206-220
dc.identifier.issn
1389-2037
dc.identifier.uri
http://hdl.handle.net/11336/229764
dc.description.abstract
The misfolding and aggregation of amyloidogenic polypeptides are characteristics of many neurodegenerative syndromes including Alzheimer´s and Parkinson´s disease. There is a major interest in the availability of amyloid-specific probes that exhibit fluorescence properties for its use as reporters of protein aggregation in spectroscopy and microscopy methodologies. In this review we intend to provide an overview of novel fluorescence-based probes and procedures applied for addressing fundamental aspects of amyloid self-assembly in vitro and in vivo. We highlight the utilization in vitro of several small-molecule fluorescent probes as extrinsic and site-specific reporters of amyloid formation, including single-molecule determinations. Detection of amyloid self-assembly employing compounds such as JC-1, DCVJ, ANS derivatives and luminescent conjugated polymers, as well as site-specific probes such as pyrene and ESIPT is discussed. We further review novel fluorescent probes developed for the non-invasive optical imaging of protein aggregates in vivo, including BTA-1, Methoxy-X04, NIAD-4 and CRANAD-2. Availability of increasingly versatile amyloid-specific fluorescent probes is having a very positive impact in the drug discovery and diagnostics fields.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FLUORESCENCE MICROSCOPY
dc.subject
NEURODEGENERATIVE DISEASES
dc.subject
STRUCTURAL BIOLOGY
dc.subject
BIOSENSORS
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Small molecule fluorescent probes for the detection of amyloid self-assembly in vitro and in vivo
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-03-05T13:22:14Z
dc.journal.volume
12
dc.journal.number
3
dc.journal.pagination
206-220
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Oak Park
dc.description.fil
Fil: Bertoncini, Carlos Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Celej, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.journal.title
Current Protein and Peptide Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/article/33134
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/138920311795860151
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