Mostrar el registro sencillo del ítem

dc.contributor.author
Rutkowski, Melanie R.
dc.contributor.author
Stephen, Tom L.
dc.contributor.author
Svoronos, Nikolaos
dc.contributor.author
Allegrezza, Michael J.
dc.contributor.author
Tesone, Amelia J.
dc.contributor.author
Perales Puchalt, Alfredo
dc.contributor.author
Brencicova, Eva
dc.contributor.author
Escovar Fadul, Ximena
dc.contributor.author
Nguyen, Jenny M.
dc.contributor.author
Cadungog, Mark G.
dc.contributor.author
Zhang, Rugang
dc.contributor.author
Salatino, Mariana
dc.contributor.author
Tchou, Julia
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Conejo Garcia, Jose R.
dc.date.available
2017-08-24T20:30:13Z
dc.date.issued
2015-01-12
dc.identifier.citation
Rutkowski, Melanie R.; Stephen, Tom L.; Svoronos, Nikolaos; Allegrezza, Michael J.; Tesone, Amelia J.; et al.; Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation; Cell Press; Cancer Cell; 27; 1; 12-1-2015; 27-40
dc.identifier.issn
1535-6108
dc.identifier.uri
http://hdl.handle.net/11336/22973
dc.description.abstract
The dominant TLR5(R392X) polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at extramucosal locations by increasing systemic IL-6, which drives mobilization of myeloid-derived suppressor cells (MDSCs). Mechanistically, expanded granulocytic MDSCs cause γδ lymphocytes in TLR5-responsive tumors to secrete galectin-1, dampening antitumor immunity and accelerating malignant progression. In contrast, IL-17 is consistently upregulated in TLR5-unresponsive tumor-bearing mice but only accelerates malignant progression in IL-6-unresponsive tumors. Importantly, depletion of commensal bacteria abrogates TLR5-dependent differences in tumor growth. Contrasting differences in inflammatory cytokines and malignant evolution are recapitulated in TLR5-responsive/unresponsive ovarian and breast cancer patients. Therefore, inflammation, antitumor immunity, and the clinical outcome of cancer patients are influenced by a common TLR5 polymorphism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bacteria
dc.subject
Tlr5
dc.subject
Myeloid-Derived Suppresor Cells
dc.subject
Tumor
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-08T14:24:43Z
dc.identifier.eissn
1878-3686
dc.journal.volume
27
dc.journal.number
1
dc.journal.pagination
27-40
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Rutkowski, Melanie R.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Stephen, Tom L.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Svoronos, Nikolaos. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Allegrezza, Michael J.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Tesone, Amelia J.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Perales Puchalt, Alfredo. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Brencicova, Eva. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Escovar Fadul, Ximena. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Nguyen, Jenny M.. The Wistar Institute. Tumor Microenvironment and Metastasis Program; Estados Unidos
dc.description.fil
Fil: Cadungog, Mark G.. Christiana Care Health System. Helen F. Graham Cancer Center; Estados Unidos
dc.description.fil
Fil: Zhang, Rugang. The Wistar Institute. Gene Expression and Regulation Program; Estados Unidos
dc.description.fil
Fil: Salatino, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Tchou, Julia. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Conejo Garcia, Jose R.. The Wistar Institute. Gene Expression and Regulation Program; Estados Unidos
dc.journal.title
Cancer Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/cancer-cell/fulltext/S1535-6108(14)00460-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ccell.2014.11.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/25533336
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293269/


Archivos asociados

Documento no disponible

Comunidades y colecciones

  • Articulos(IBYME) [1100]
    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Mostrar el registro sencillo del ítem