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dc.contributor.author
Romaniuk, María Albertina
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Schattner, Mirta Ana
dc.date.available
2017-08-24T20:27:57Z
dc.date.issued
2015-01
dc.identifier.citation
Romaniuk, María Albertina; Rabinovich, Gabriel Adrián; Schattner, Mirta Ana; Galectins in the regulation of platelet biology; Humana Press; Methods In Molecular Biology (clifton, N.j.); 1207; 1-2015; 269-283
dc.identifier.isbn
978-1-4939-1396-1
dc.identifier.issn
1064-3745
dc.identifier.uri
http://hdl.handle.net/11336/22970
dc.description.abstract
Platelets are anucleated blood cells derived from megakaryocytes, and although they are essential for proper hemostasis, their function extends to physiologic processes such as tissue repair, wound remodeling, and antimicrobial host defense, or pathologic conditions such as thrombosis, atherosclerosis, chronic inflammatory diseases, and cancer. Recently, we demonstrated that two structurally divergent members of the galectin family, galectin-1 and galectin-8, are potent platelet agonists. The emergence of galectins as soluble mediators capable of triggering platelet activation opens a new field of research that will provide further insights into the mechanisms linking inflammatory responses to thrombus formation and could expand our view of the role of platelets much beyond hemostasis to their pathophysiologic role during inflammation and cancer. The present article details the various protocols and reagents currently used in our laboratory to study the role of galectins in human platelet function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Galectins
dc.subject
Platelets
dc.subject
Glycobiology
dc.subject
Inflammation
dc.subject
P-Selectin
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Galectins in the regulation of platelet biology
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-08T14:24:37Z
dc.identifier.eissn
1940-6029
dc.journal.volume
1207
dc.journal.pagination
269-283
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Romaniuk, María Albertina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Methods In Molecular Biology (clifton, N.j.)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-4939-1396-1_17
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-4939-1396-1_17
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/25253146


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