Artículo

Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth

Izzo, FrancoIcon ; Mercogliano, María FlorenciaIcon ; Venturutti, LeandroIcon ; Tkach, MercedesIcon ; Inurrigarro, Gloria; Schillaci, RoxanaIcon ; Cerchietti, Leandro; Elizalde, Patricia VirginiaIcon ; Proietti Anastasi, Cecilia JazmínIcon
Fecha de publicación: 06/12/2014
Editorial: BioMed Central
Revista: Breast Cancer Research
ISSN: 1465-5411
e-ISSN: 1465-542X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The transcription factor GATA3 is involved in mammary gland development and is crucial for the maintenance of the differentiated status of luminal epithelial cells. The role of GATA3 in breast cancer as a tumor suppressor has been established, although insights into the mechanism of GATA3 expression loss are still required.
Palabras clave: Gata3 , Breast Cancer , Progesterone , Mammary Neoplasms , Cyclin A2
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/22962
URL: https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-014-049
DOI: http://dx.doi.org/10.1186/s13058-014-0491-x
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303201/
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Izzo, Franco; Mercogliano, María Florencia; Venturutti, Leandro; Tkach, Mercedes; Inurrigarro, Gloria; et al.; Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth; BioMed Central; Breast Cancer Research; 16; 6; 6-12-2014; 491-491
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