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dc.contributor.author
Ponsone, Maria Lorena  
dc.contributor.author
Kuhn, Yamila Gisele  
dc.contributor.author
Schmidt Heydt, M.  
dc.contributor.author
Geisen, R.  
dc.contributor.author
Chulze, Sofia Noemi  
dc.date.available
2017-08-24T19:32:44Z  
dc.date.issued
2013-06  
dc.identifier.citation
Ponsone, Maria Lorena; Kuhn, Yamila Gisele; Schmidt Heydt, M.; Geisen, R.; Chulze, Sofia Noemi; Effect of Kluyveromyces thermotolerans on polyketide synthase gene expression and ochratoxin accumulation by Penicillium and Aspergillus; Wageningen Academic Publishers; World Mycotoxin Journal; 6; 3; 6-2013; 291-297  
dc.identifier.issn
1875-0710  
dc.identifier.uri
http://hdl.handle.net/11336/22949  
dc.description.abstract
In a previous study, it was demonstrated that Kluyveromyces thermotolerans strains can reduce both growth and ochratoxin A (OTA) accumulation by Aspergillus section Nigri strains. There is no information about the mechanisms related to this reduction. A viable hypothesis can be that the presence of biocontrol agents can affect OTA biosynthesis by influencing the transcriptional activity of the polyketide synthase (pks) gene, one of the key enzymes in the OTA biosynthetic pathway. The aims of this work were to determine the effect of two selected strains of K. thermotolerans as potential biocontrol agents and to evaluate if their presence can affect the otapks gene expression of ochratoxigenic Aspergillus and Penicillium species. Growth, OTA and ochratoxin B (OTB) biosynthesis by the fungal strains at the phenotypic and molecular levels were monitored. The results obtained showed that both K. thermotolerans strains evaluated had a strong influence on growth, OTA and OTB biosynthesis, and expression of the mycotoxin biosynthesis genes. However, no direct correlation between the influence of the biocontrol yeasts on pks gene expression, OTA and OTB production could be found. These results could indicate an inhibitory mechanism by the yeasts, which apparently involve a post-transcriptional mechanism. The data obtained could imply that the production of mycotoxins can be regarded as a kind of adaptation mechanism to environmental stress conditions by these mycotoxigenic species.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wageningen Academic Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Biocontrol  
dc.subject
Kuyveromyces Thermotolerans  
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Ochratoxigenic Species  
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Ochratoxins  
dc.subject.classification
Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Effect of Kluyveromyces thermotolerans on polyketide synthase gene expression and ochratoxin accumulation by Penicillium and Aspergillus  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-08-24T18:02:18Z  
dc.identifier.eissn
1875-0796  
dc.journal.volume
6  
dc.journal.number
3  
dc.journal.pagination
291-297  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Ponsone, Maria Lorena. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Kuhn, Yamila Gisele. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Schmidt Heydt, M.. Max Rubner Institut; Alemania  
dc.description.fil
Fil: Geisen, R.. Max Rubner Institut; Alemania  
dc.description.fil
Fil: Chulze, Sofia Noemi. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
World Mycotoxin Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3920/WMJ2012.1532  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.wageningenacademic.com/doi/10.3920/WMJ2012.1532