Artículo
Comprehensive Analysis of Equid Herpesvirus Recombination: An Insight Into the Repeat Regions
Tau, Rocío Lucía
; Ferreccio, Carola Maria
; Bachir, Natalia Veronica
; Torales, Fátima Anabel; Romera, Sonia
; Maidana, Silvina Soledad
Fecha de publicación:
09/2023
Editorial:
Elsevier Science Inc.
Revista:
Journal of Equine Veterinary Science
ISSN:
0737-0806
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
High-throughput sequencing of genomes has expanded our knowledge of the Alphaherpesvirinae, a widely extended subfamily of DNA viruses that recombine to increase their genetic diversity. It has been acknowledged that Equid herpesvirus 1 (EHV-1) and equid herpesvirus 4 (EHV-4), two alphaherpesviruses with an economic impact on the horse industry, can recombine. This work aimed to analyze interspecific recombination between all equid alphaherpesvirus species, using genomes of EHV-1, EHV-3, EHV-4, EHV-6, EHV-8, and EHV-9 available in GenBank. 14 events of recombination by RDP4 and Simplot between EHV-1 x EHV-4, EHV-1 x EHV-9, EHV-8 x EHV-1, and EHV-8 x EHV-9 were identified. 10 out of 14 events involved ORF64, a double-copy gene located at the repeat regions that codifies for the infected cell protein 4 (ICP4). Among the ICP4, recombination can be found between EHV-1 X EHV-9, EHV-8 X EHV-9, and EHV-1 X EHV-4, the former affects zebra-borne genotypes, a type of EHV-1 that infect wild equids, and the latter match with previous breakpoints reported in fields isolates. Consequently, these findings strongly suggest that ICP4 is a hotspot for recombination. This work describes novel recombination events and is the first genome-wide recombination analysis using all available equid alphaherpesvirus species genomes.
Palabras clave:
ALPHAHERPESVIRUS
,
EQUID
,
HOMOLOGUS
,
ICP4
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IVIT)
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Citación
Tau, Rocío Lucía; Ferreccio, Carola Maria; Bachir, Natalia Veronica; Torales, Fátima Anabel; Romera, Sonia; et al.; Comprehensive Analysis of Equid Herpesvirus Recombination: An Insight Into the Repeat Regions; Elsevier Science Inc.; Journal of Equine Veterinary Science; 130; 9-2023; 1-13
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