Artículo
MobiDB: 10 years of intrinsically disordered proteins
Piovesan, Damiano; Del Conte, Alessio; Clementel, Damiano; Monzon, Alexander Miguel; Bevilacqua, Martina; Aspromonte, Maria Cristina; Iserte, Javier Alonso
; Orti, Fernando Ezequiel
; Marino Buslje, Cristina; Tosatto, Silvio C. E.
Fecha de publicación:
01/2023
Editorial:
Oxford University Press
Revista:
Nucleic Acids Research
e-ISSN:
1362-4962
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The MobiDB database (URL: https://mobidb.org/) is a knowledge base of intrinsically disordered proteins. MobiDB aggregates disorder annotations derived from the literature and from experimental evidence along with predictions for all known protein sequences. MobiDB generates new knowledge and captures the functional significance of disordered regions by processing and combining complementary sources of information. Since its first release 10 years ago, the MobiDB database has evolved in order to improve the quality and coverage of protein disorder annotations and its accessibility. MobiDB has now reached its maturity in terms of data standardization and visualization. Here, we present a new release which focuses on the optimization of user experience and database content. The major advances compared to the previous version are the integration of AlphaFoldDB predictions and the re-implementation of the homology transfer pipeline, which expands manually curated annotations by two orders of magnitude. Finally, the entry page has been restyled in order to provide an overview of the available annotations along with two separate views that highlight structural disorder evidence and functions associated with different binding modes.
Palabras clave:
Intrinsically disordered proteins
,
Database
,
Predictions
,
MobiDB
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Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Piovesan, Damiano; Del Conte, Alessio; Clementel, Damiano; Monzon, Alexander Miguel; Bevilacqua, Martina; et al.; MobiDB: 10 years of intrinsically disordered proteins; Oxford University Press; Nucleic Acids Research; 51; 1 D; 1-2023; D438-D444
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