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dc.contributor.author
Bessone, Fernando
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Ferrari, Antonella
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Hernandez, Nelia
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Mendizabal, Manuel
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Ridruejo, Ezequiel
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Zerega, Alina
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Tanno, Federico Carlos
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Reggiardo, María Virginia
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Vorobioff, Julio
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Tanno, Hugo Enrique
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Arrese, Marco
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Nunes, Vinicius
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Tagle, Martin
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Medina Caliz, Inmaculada
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Robles Diaz, Mercedes
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Niu, Hao
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Alvarez Alvarez, Ismael
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Stephens, Camilla
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Lucena, M. Isabel
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Andrade, Raul J.
dc.date.available
2024-02-28T14:21:33Z
dc.date.issued
2023-02
dc.identifier.citation
Bessone, Fernando; Ferrari, Antonella; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; et al.; Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries; Springer; Archives of Toxicology; 97; 2; 2-2023; 593-602
dc.identifier.issn
0340-5761
dc.identifier.uri
http://hdl.handle.net/11336/228818
dc.description.abstract
Nitrofurantoin is a synthetic antibiotic that is recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American countries. We described the demographics, clinical characteristics, biochemical features, and outcome of nitrofurantoin-induced liver injury. We analyzed 23 cases from the Latin American DILI Network (LATINDILI) and the Spanish DILI Registry. Causality was assessed with the RUCAM and RECAM scale. Of the 23 DILI cases included in our series, 96% patients were women, and the mean age of the whole cohort was 61 years. The median time of drug exposure was 175 days (interquartile range [IQR] 96–760), with 11 patients who were prescribed nitrofurantoin for more than six months. Hepatocellular damage was the most frequent pattern of liver injury (83%), and nearly half of the patients had an asymptomatic presentation (52%). Neither death nor liver transplantation was documented in this series. Overall, 65% of the patients (n = 15) presented with positive autoantibody titres. The median time to resolution was 81 days (IQR 57–141), and 15 patients (83%) recovered within six months. Five patients (22%) developed nitrofurantoin-induced autoimmune-like hepatitis (NI-AILH), of whom two were characterized by a persistent increase in transaminases that required immunosuppressive treatment to achieve normalization of liver enzymes. Clinicians who prescribe nitrofurantoin should be aware that patients who had taken nitrofurantoin for a long term may be at risk of developing nitrofurantoin-induced autoimmune-like hepatitis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTOIMMUNE-LIKE HEPATITIS
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DRUG-INDUCED LIVER INJURY
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HEPATOTOXICITY
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NITROFURANTOIN
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Gastroenterología y Hepatología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries
dc.type
info:eu-repo/semantics/article
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info:ar-repo/semantics/artículo
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info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-28T10:36:23Z
dc.journal.volume
97
dc.journal.number
2
dc.journal.pagination
593-602
dc.journal.pais
Alemania
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dc.description.fil
Fil: Bessone, Fernando. Hospital Provincial del Centenario; Argentina
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Fil: Ferrari, Antonella. Hospital Provincial del Centenario; Argentina
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Fil: Hernandez, Nelia. Hospital de Clinicas Dr. Manuel Quintela; Uruguay
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Fil: Mendizabal, Manuel. Universidad Austral; Argentina
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Fil: Ridruejo, Ezequiel. Centro de Educación Medica E Invest.clinicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Zerega, Alina. Hospital Allende; Argentina
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Fil: Tanno, Federico Carlos. Hospital Provincial del Centenario; Argentina
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Fil: Reggiardo, María Virginia. Hospital Provincial del Centenario; Argentina
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Fil: Vorobioff, Julio. Hospital Provincial del Centenario; Argentina
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Fil: Tanno, Hugo Enrique. Hospital Provincial del Centenario; Argentina
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Fil: Arrese, Marco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
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Fil: Nunes, Vinicius. Universidade Federal da Bahia; Brasil
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Fil: Tagle, Martin. Clínica Anglo Americana; Perú
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Fil: Medina Caliz, Inmaculada. Universidad de Málaga; España
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Fil: Robles Diaz, Mercedes. Universidad de Málaga; España
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Fil: Niu, Hao. Universidad de Málaga; España
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Fil: Alvarez Alvarez, Ismael. Universidad de Málaga; España
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Fil: Stephens, Camilla. Universidad de Málaga; España
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Fil: Lucena, M. Isabel. Universidad de Málaga; España
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Fil: Andrade, Raul J.. Universidad de Málaga; España
dc.journal.title
Archives of Toxicology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00204-022-03419-7
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00204-022-03419-7
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