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dc.contributor.author
Coalova, Isis
dc.contributor.author
March, Hugo
dc.contributor.author
Rios, Maria del Carmen
dc.contributor.author
Chaufan, Gabriela
dc.date.available
2024-02-27T12:20:19Z
dc.date.issued
2023-02
dc.identifier.citation
Coalova, Isis; March, Hugo; Rios, Maria del Carmen; Chaufan, Gabriela; Individual and joint effects of glyphosate and cypermethrin formulations on two human cell lines; Academic Press Inc Elsevier Science; Toxicology and Applied Pharmacology; 461; 2-2023; 1-9
dc.identifier.issn
0041-008X
dc.identifier.uri
http://hdl.handle.net/11336/228536
dc.description.abstract
The final effect of pesticides and their mixtures on living organisms is determined by the particular toxicodynamics of the system. Oxidative stress is one of the most studied molecular mechanisms of toxicity due to increasing evidence supporting its association with the toxic effects of different agrochemicals. In the present study we evaluated the presence of redox balance alterations in the cell lines HEp-2 and A549 exposed to formulations of glyphosate (March®) and cypermethrin (Superfina®) used separately or in combination (in a proportion equivalent to that used in soybean fields). We determined the activity of catalase, superoxide dismutase, glutathione S-transferase, intracellular GSH content, content of oxidized proteins (as measure of damage) and intracellular ROS content in both cell lines at two different mixture concentrations. Additionally, we evaluated the presence of statistical interaction to determine if the effect of the mixture on the parameters evaluated was additive, synergistic, or antagonistic. For this purpose, we used the Combination Subthresholding, Cooperative Effect and Statistical Linear Interaction approaches. We found that the interaction between pesticides depended on their concentration and the cellular models studied.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGROCHEMICALS
dc.subject
CELL LINE
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JOINT TOXICITY
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OXIDATIVE STRESS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Individual and joint effects of glyphosate and cypermethrin formulations on two human cell lines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-26T11:12:07Z
dc.journal.volume
461
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Coalova, Isis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: March, Hugo. No especifíca;
dc.description.fil
Fil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Chaufan, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title
Toxicology and Applied Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.taap.2023.116398
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