Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs

Diabetes mellitus is characterized by chronic hyperglycemia with loss of β-cell function and mass. An attractive therapeutic approach to treat patients with diabetes in a non-invasive way is to harness the innate regenerative potential of the pancreas. The Islet Neogenesis-Associated Protein pentadecapeptide (INGAP-PP) has been shown to induce β-cell regeneration and improve their function in rodents. To investigate its possible mechanism of action, we report here the global transcriptional effects induced by the short-term INGAP-PP in vitro treatment of adult rat pancreatic islets.

Palabras clave: Diabetes mellitus , Epigenomics , Non-coding RNAs

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)

Identificadores

URI: http://hdl.handle.net/11336/228321

URL: https://www.frontiersin.org/articles/10.3389/fendo.2023.1226615/full

DOI: http://dx.doi.org/10.3389/fendo.2023.1226615

Colecciones

Articulos(CENEXA)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)

Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS

Citación

Romero, Agustín; Heidenreich, Ana Carolina; Román, Carolina Lisi; Algañarás, Macarena; Nazer, Ezequiel; et al.; Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs; Frontiers Media; Frontiers in Endocrinology; 14; 1226615; 9-2023; 1-13

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