Artículo
Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
Cardona Londoño, Juan Felipe
; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos
; Lee Houck, Alexander; Cardona, Sebastián; Kargieman, Lucila
; Trujillo, Natalia; Arévalo, Analía; Amoruso, Lucía
; Manes, Facundo Francisco
; Ibañez, Agustin Mariano
Fecha de publicación:
02/2013
Editorial:
Springer Heidelberg
Revista:
Brain Structure & Function
ISSN:
1863-2653
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson´s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical-subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action-perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.
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Citación
Cardona Londoño, Juan Felipe; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos; Lee Houck, Alexander; Cardona, Sebastián; et al.; Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling; Springer Heidelberg; Brain Structure & Function; 218; 6; 2-2013; 1355-1373
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