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dc.contributor.author
Accordino, Sebastian Roberto
dc.contributor.author
Rodriguez Fris, Jorge Ariel
dc.contributor.author
Appignanesi, Gustavo Adrian
dc.contributor.author
Fernández, A.
dc.date.available
2024-02-23T11:13:43Z
dc.date.issued
2012-03
dc.identifier.citation
Accordino, Sebastian Roberto; Rodriguez Fris, Jorge Ariel; Appignanesi, Gustavo Adrian; Fernández, A.; A unifying motif of intermolecular cooperativity in protein associations; Springer; European Physical Journal E; 35; 7; 3-2012; 1-7
dc.identifier.issn
1292-8941
dc.identifier.uri
http://hdl.handle.net/11336/228132
dc.description.abstract
At the molecular level, most biological processes entail protein associations which in turn rely on a small fraction of interfacial residues called hot spots. Our theoretical analysis shows that hot spots share a unifying molecular attribute: they provide a third-body contribution to intermolecular cooperativity. Such motif, based on the wrapping of interfacial electrostatic interactions, is essential to maintain the integrity of the interface. Thus, our main result is to unravel the molecular nature of the protein association problem by revealing its underlying physics and thus by casting it in simple physical grounds. Such knowledge could then be exploited in rational drug design since the regions here indicated may serve as blueprints to engineer small molecules disruptive of protein-protein interfaces.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PROTEINS
dc.subject
BINDING
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HOT SPOTS
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ALANINE SCANNING
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A unifying motif of intermolecular cooperativity in protein associations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-09T14:23:15Z
dc.identifier.eissn
1292-895X
dc.journal.volume
35
dc.journal.number
7
dc.journal.pagination
1-7
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Accordino, Sebastian Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Rodriguez Fris, Jorge Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Appignanesi, Gustavo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Fernández, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina
dc.journal.title
European Physical Journal E
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1140/epje/i2012-12059-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1140/epje/i2012-12059-0
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