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Artículo

An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor

Abulafia, Carolina AndreaIcon ; Vidal, María Fernanda; Olivar, Natividad; Odzak, Andrea; Brusco, Luis IgnacioIcon ; Guinjoan, Salvador MartínIcon ; Cardinali, Daniel PedroIcon ; Vigo, Daniel EduardoIcon
Fecha de publicación: 05/2023
Editorial: Dove Press
Revista: Clinical Interventions in Aging
e-ISSN: 1178-1998
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population.
Palabras clave: HEART RATE VARIABILITY , ACTIGRAPHY , CIRCADIAN RHYTHMS , WAVELETS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/227966
URL: https://www.dovepress.com/an-exploratory-study-of-sleep-wake-differences-of-auto
DOI: http://dx.doi.org/10.2147/CIA.S394749
Colecciones
Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Citación
Abulafia, Carolina Andrea; Vidal, María Fernanda; Olivar, Natividad; Odzak, Andrea; Brusco, Luis Ignacio; et al.; An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor; Dove Press; Clinical Interventions in Aging; 18; 5-2023; 771-781
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