Artículo
COVID-19 vaccines reduce mortality in hospitalized patients with oxygen requirements: Differences between vaccine subtypes: A multicontinental cohort study
Huespe, Ivan; Ferraris, Augusto; Lalueza, Antonio; Valdez, Pascual; Peroni, María Leticia; Cayetti, Luis A.; Mirofsky, Matias A.; Boietti, Bruno Rafael; Gómez Huelgas, Ricardo; Casas Rojo, José M.; Antón Santos, Juan M.; Núñez Cortés, Jesús M.; Lumbreras, Carlos; Ramos Rincón, Jose Manuel; Barrio, Noelia G.; Pedrera Jiménez, Miguel; Martin Escalante, María D.; Ruiz, Francisco R.; Onieva García, María Á.; Toso, Carlos R.; Risk, Marcelo
; Klén, Riku; Pollán, Javier A.; Gómez Varela, David
Fecha de publicación:
05/2023
Editorial:
Wiley-liss, div John Wiley & Sons Inc.
Revista:
Journal of Medical Virology
ISSN:
0146-6615
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this study was to analyze whether the coronavirus disease 2019 (COVID-19) vaccine reduces mortality in patients with moderate or severe COVID-19 disease requiring oxygen therapy. A retrospective cohort study, with data from 148 hospitals in both Spain (111 hospitals) and Argentina (37 hospitals), was conducted. We evaluated hospitalized patients for COVID-19 older than 18 years with oxygen requirements. Vaccine protection against death was assessed through a multivariable logistic regression and propensity score matching. We also performed a subgroup analysis according to vaccine type. The adjusted model was used to determine the population attributable risk. Between January 2020 and May 2022, we evaluated 21,479 COVID-19 hospitalized patients with oxygen requirements. Of these, 338 (1.5%) patients received a single dose of the COVID-19 vaccine and 379 (1.8%) were fully vaccinated. In vaccinated patients, mortality was 20.9% (95% confidence interval [CI]: 17.9–24), compared to 19.5% (95% CI: 19–20) in unvaccinated patients, resulting in a crude odds ratio (OR) of 1.07 (95% CI: 0.89–1.29; p = 0.41). However, after considering the multiple comorbidities in the vaccinated group, the adjusted OR was 0.73 (95% CI: 0.56–0.95; p = 0.02) with a population attributable risk reduction of 4.3% (95% CI: 1–5). The higher risk reduction for mortality was with messenger RNA (mRNA) BNT162b2 (Pfizer) (OR 0.37; 95% CI: 0.23–0.59; p < 0.01), ChAdOx1 nCoV-19 (AstraZeneca) (OR 0.42; 95% CI: 0.20–0.86; p = 0.02), and mRNA-1273 (Moderna) (OR 0.68; 95% CI: 0.41–1.12; p = 0.13), and lower with Gam-COVID-Vac (Sputnik) (OR 0.93; 95% CI: 0.6–1.45; p = 0.76). COVID-19 vaccines significantly reduce the probability of death in patients suffering from a moderate or severe disease (oxygen therapy).
Palabras clave:
COVID-19
,
COVID-19 VACCINES
,
HOSPITALIZATION
,
OXYGEN THERAPY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IMTIB)
Articulos de INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Articulos de INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Citación
Huespe, Ivan; Ferraris, Augusto; Lalueza, Antonio; Valdez, Pascual; Peroni, María Leticia; et al.; COVID-19 vaccines reduce mortality in hospitalized patients with oxygen requirements: Differences between vaccine subtypes: A multicontinental cohort study; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 95; 5; 5-2023; 1-10
Compartir
Altmétricas