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dc.contributor.author
Romeo, Horacio Eduardo  
dc.contributor.author
Barreiro Arcos, María Laura  
dc.date.available
2024-02-22T11:05:23Z  
dc.date.issued
2023-06  
dc.identifier.citation
Romeo, Horacio Eduardo; Barreiro Arcos, María Laura; Clinical relevance of stem cells in lung cancer; Baishideng Publishing Group; World Journal of Stem Cells; 15; 6; 6-2023; 576-588  
dc.identifier.uri
http://hdl.handle.net/11336/227938  
dc.description.abstract
Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is the most common lung cancer, accounting for 85% of all lung cancers. Treatment for lung cancer is linked to the cell type and stage of the disease, involving chemotherapy, radiation therapy, and surgery. Despite improvements in therapeutic treatments, lung cancer patients show high rates of recurrence, metastasis, and resistance to chemotherapy. Lung stem cells (SCs) are undifferentiated cells capable of self-renewal and proliferation, are resistant to chemotherapy and radiotherapy and, due to their properties, could be involved in the development and progression of lung cancer. The presence of SCs in the lung tissue could be the reason why lung cancer is difficult to treat. The identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell populations. In this review, we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer, as well as their role in tumor resistance to chemotherapy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Baishideng Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BIOMARKERS  
dc.subject
CANCER STEM CELLS  
dc.subject
CHEMORESISTANCE  
dc.subject
LUNG CANCER  
dc.subject.classification
Patología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Clinical relevance of stem cells in lung cancer  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-02-20T12:31:07Z  
dc.identifier.eissn
1948-0210  
dc.journal.volume
15  
dc.journal.number
6  
dc.journal.pagination
576-588  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Pleasanton  
dc.description.fil
Fil: Romeo, Horacio Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina  
dc.description.fil
Fil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina  
dc.journal.title
World Journal of Stem Cells  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1948-0210/full/v15/i6/576.htm  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4252/wjsc.v15.i6.576