Artículo
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Mathieu, Patricia Andrea
; Rodriguez Sampertegui, Yim; Elias, Fernanda; Silva Silva, Alexis Eduardo
; de Luján Calcagno, María; López, Ricardo; Adamo, Ana María
Fecha de publicación:
12/2023
Editorial:
Humana Press
Revista:
Molecular Neurobiology
ISSN:
0893-7648
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resulting from oligodendrocyte loss and inflammation. Cuprizone (CPZ) administration experimentally replicates MS pattern-III lesions, generating an inflammatory response through microgliosis and astrogliosis. Potentially remyelinating agents include oligodeoxynucleotides (ODN) with a specific immunomodulatory sequence consisting of the active motif PyNTTTTGT. In this work, the remyelinating effects of ODN IMT504 were evaluated through immunohistochemistry and qPCR analyses in a rat CPZ-induced demyelination model. Subcutaneous IMT504 administration exacerbated the pro-inflammatory response to demyelination and accelerated the transition to an anti-inflammatory state. IMT504 reduced microgliosis in general and the number of phagocytic microglia in particular and expanded the population of oligodendroglial progenitor cells (OPCs), later reflected in an increase in mature oligodendrocytes. The intracranial injection of IMT504 and intravenous inoculation of IMT504-treated B lymphocytes rendered comparable results. Altogether, these findings unveil potentially beneficial properties of IMT504 in the regulation of neuroinflammation and oligodendrogenesis, which may aid the development of therapies for demyelinating diseases such as MS.
Palabras clave:
CUPRIZONE
,
DEMYELINATION
,
OLIGODEOXYNUCLEOTIDE IMT504
,
REMYELINATION
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Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Mathieu, Patricia Andrea; Rodriguez Sampertegui, Yim; Elias, Fernanda; Silva Silva, Alexis Eduardo; de Luján Calcagno, María; et al.; Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination; Humana Press; Molecular Neurobiology; 12-2023; 1-20
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