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Artículo

Comparative genome analysis of the genus Shewanella unravels the association of key genetic traits with known and potential pathogenic lineages

Cerbino, Gabriela NoraIcon ; Traglia, German MatiasIcon ; Ayala Nuñez, TeolincacihuatlIcon ; Parmeciano Di Noto, Gisela PaulaIcon ; Ramirez, Maria SoledadIcon ; Centron, DanielaIcon ; Iriarte, Andres; Quiroga, CeciliaIcon
Fecha de publicación: 02/2023
Editorial: Frontiers Media
Revista: Frontiers in Microbiology
e-ISSN: 1664-302X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Shewanella spp. are Gram-negative rods widely disseminated in aquatic niches that can also be found in human-associated environments. In recent years, reports of infections caused by these bacteria have increased significantly. Mobilome and resistome analysis of a few species showed that they are versatile; however, comprehensive comparative studies in the genus are lacking. Here, we analyzed the genetic traits of 144 genomes from Shewanella spp. isolates focusing on the mobilome, resistome, and virulome to establish their evolutionary relationship and detect unique features based on their genome content and habitat. Shewanella spp. showed a great diversity of mobile genetic elements (MGEs), most of them associated with monophyletic lineages of clinical isolates. Furthermore, 79/144 genomes encoded at least one antimicrobial resistant gene with their highest occurrence in clinical-related lineages. CRISPR-Cas systems, which confer immunity against MGEs, were found in 41 genomes being I-E and I-F the more frequent ones. Virulome analysis showed that all Shewanella spp. encoded different virulence genes (motility, quorum sensing, biofilm, adherence, etc.) that may confer adaptive advantages for survival against hosts. Our data revealed that key accessory genes are frequently found in two major clinical-related groups, which encompass the opportunistic pathogens Shewanella algae and Shewanella xiamenensis together with several other species. This work highlights the evolutionary nature of Shewanella spp. genomes, capable of acquiring different key genetic traits that contribute to their adaptation to different niches and facilitate the emergence of more resistant and virulent isolates that impact directly on human and animal health.
Palabras clave: ACCESSORY GENOME , HORIZONTAL GENE TRANSFER , MOBILOME , RESISTOME , SHEWANELLA , VIRULOME
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/227805
DOI: https://doi.org/10.3389/fmicb.2023.1124225
URL: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.11
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Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Cerbino, Gabriela Nora; Traglia, German Matias; Ayala Nuñez, Teolincacihuatl; Parmeciano Di Noto, Gisela Paula; Ramirez, Maria Soledad; et al.; Comparative genome analysis of the genus Shewanella unravels the association of key genetic traits with known and potential pathogenic lineages; Frontiers Media; Frontiers in Microbiology; 14; 1124225; 2-2023; 1-15
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