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dc.contributor.author
Colavitta, María Florencia
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dc.contributor.author
Barrantes, Francisco Jose
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dc.date.available
2024-02-21T13:16:47Z
dc.date.issued
2023-08
dc.identifier.citation
Colavitta, María Florencia; Barrantes, Francisco Jose; Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease; MDPI; Pharmaceutics; 15; 8; 8-2023; 1-23
dc.identifier.uri
http://hdl.handle.net/11336/227770
dc.description.abstract
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people. Owing to its varied and multicausal etiopathology, intervention strategies have been highly diverse. Despite ongoing advances in the field, efficient therapies to mitigate AD symptoms or delay their progression are still of limited scope. Neuroplasticity, in broad terms the ability of the brain to modify its structure in response to external stimulation or damage, has received growing attention as a possible therapeutic target, since the disruption of plastic mechanisms in the brain appear to correlate with various forms of cognitive impairment present in AD patients. Several pre-clinical and clinical studies have attempted to enhance neuroplasticity via different mechanisms, for example, regulating glucose or lipid metabolism, targeting the activity of neurotransmitter systems, or addressing neuroinflammation. In this review, we first describe several structural and functional aspects of neuroplasticity. We then focus on the current status of pharmacological approaches to AD stemming from clinical trials targeting neuroplastic mechanisms in AD patients. This is followed by an analysis of analogous pharmacological interventions in animal models, according to their mechanisms of action.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ALZHEIMER DISEASE
dc.subject
COGNITION
dc.subject
COGNITIVE IMPAIRMENT: ANIMAL MODELS
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DEMENTIAS
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LONG-TERM POTENTIATION
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NEURODEGENERATIVE DISEASES
dc.subject
NEUROINFLAMMATION
dc.subject
NEUROPLASTICITY
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NEUROTRANSMITTERS
dc.subject
THERAPEUTICS
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-20T12:25:04Z
dc.identifier.eissn
1999-4923
dc.journal.volume
15
dc.journal.number
8
dc.journal.pagination
1-23
dc.journal.pais
Suiza
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dc.journal.ciudad
Basilea
dc.description.fil
Fil: Colavitta, María Florencia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/pharmaceutics15082052
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