Artículo
Cooperativity in regulation of membrane protein function: phenomenological analysis of the effects of pH and phospholipids
Zerbetto de Palma, Gerardo Gabriel
; Recoulat Angelini, Alvaro Agustin
; Vitali, Victoria Andrea
; Gonzalez Flecha, Francisco Luis
; Alleva, Karina Edith
Fecha de publicación:
07/2023
Editorial:
Springer
Revista:
Biophysical Reviews
ISSN:
1867-2450
e-ISSN:
1867-2469
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Interaction between membrane proteins and ligands plays a key role in governing a wide spectrum of cellular processes. These interactions can provide a cooperative-type regulation of protein function. A wide variety of proteins, including enzymes, channels, transporters, and receptors, displays cooperative behavior in their interactions with ligands. Moreover, the ligands involved encompass a vast diversity and include specific molecules or ions that bind to specific binding sites. In this review, our particular focus is on the interaction between integral membrane proteins and ligands that can present multiple “binding sites”, such as protons or membrane phospholipids. The study of the interaction that protons or lipids have with membrane proteins often presents challenges for classical mechanistic modeling approaches. In this regard, we show that, like Hill’s pioneering work on hemoglobin regulation, phenomenological modeling constitutes a powerful tool for capturing essential features of these systems.
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Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Zerbetto de Palma, Gerardo Gabriel; Recoulat Angelini, Alvaro Agustin; Vitali, Victoria Andrea; Gonzalez Flecha, Francisco Luis; Alleva, Karina Edith; Cooperativity in regulation of membrane protein function: phenomenological analysis of the effects of pH and phospholipids; Springer; Biophysical Reviews; 15; 4; 7-2023; 721-731
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