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dc.contributor.author
Urueña, Lourdes Analía
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dc.contributor.author
Badano, Maria Noel
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dc.contributor.author
Baré, Patricia
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dc.contributor.author
Gonzalez, Jorge
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Vicentin, Rosalía
dc.contributor.author
Calli, R.
dc.contributor.author
Cañero Velasco, Maria Cristina
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dc.contributor.author
Goldstein, Susana Beatriz
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dc.contributor.author
Vizzotti, Carla
dc.date.available
2024-02-21T12:44:53Z
dc.date.issued
2022-01
dc.identifier.citation
Urueña, Lourdes Analía; Badano, Maria Noel; Baré, Patricia; Gonzalez, Jorge; Vicentin, Rosalía; et al.; Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children; Elsevier; Vaccine; 40; 1; 1-2022; 114-121
dc.identifier.issn
0264-410X
dc.identifier.uri
http://hdl.handle.net/11336/227736
dc.description.abstract
Infants’ universal hepatitis A virus (HAV) single-dose vaccination has been highly effective for controlling HAV infection in Argentina, and in other Latin-American countries that adopted that strategy. Although antibodies wane over time, this has not been associated with HAV outbreaks or breakthrough infections, suggesting a relevant role for memory immunity. This study assessed long term humoral and cellular immune memory response after an average of 12 years follow-up of HAV single-dose vaccination. We selected 81 HAV-single dose vaccinated individuals from a 2015 study, including 54 with unprotective (UAL) and 27 with protective antibody levels (PAL) against HAV. Humoral memory response was assessed by measuring anti-HAV antibody titers at admission in both groups, and 30 days after a booster dose in the UAL group. Flow cytometry analysis of peripheral blood mononuclear cell samples stimulated with HAV antigen was performed in 47/81 individuals (21 with PAL, 26 with UAL) to identify activated CD4 + memory T cells or CD8 + memory T cells. The results showed that 48/52 (92%) individuals from UAL group who completed follow up reached protective levels after booster dose. In the PAL group, anti-HAV Abs waned in 2/27 (7%) individuals lacking seroprotection, while in 25/27 (93%) Abs remained >10 mUI/mL. HAV-specific memory CD4 + T cells were detected in 25/47 (53.2%) subjects while HAV-specific memory CD8 + T cells were observed in 16/47 (34.04%) individuals. HAV-specific memory CD4+ and CD8+ T cell responses were detected in 11/21 (52.4%) and in 9/21 (42.9%) subjects with PAL and in 14/26 (53.8%) and in 7/26 (26.9%) individuals with UAL, showing that the presence of memory T-cells was independent of the level or presence of anti-HAV antibodies. Long-term immunity demonstrated in the present work, including or not antibody persistence, suggests that individuals with waned Ab titers may still be protected and supports the single-dose HAV strategy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Virus de la hepatitis A
dc.subject
Vacunación
dc.subject
Inmunidad
dc.subject
Respuesta de memoria
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-20T15:02:39Z
dc.journal.volume
40
dc.journal.number
1
dc.journal.pagination
114-121
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Urueña, Lourdes Analía. Universidad Isalud; Argentina
dc.description.fil
Fil: Badano, Maria Noel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Gonzalez, Jorge. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
dc.description.fil
Fil: Vicentin, Rosalía. Gobierno de la Provincia de Santa Fe. Hospital de Niños Doctor Orlando Alassia.; Argentina
dc.description.fil
Fil: Calli, R.. Gobierno de la Provincia de Tucuman. Ministerio de Salud Publica. Direccion de Epidemiologia.; Argentina
dc.description.fil
Fil: Cañero Velasco, Maria Cristina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
dc.description.fil
Fil: Goldstein, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Vizzotti, Carla. Universidad Isalud; Argentina
dc.journal.title
Vaccine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X21014821
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.vaccine.2021.11.037
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