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dc.contributor.author
Schattner, Mirta Ana
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dc.date.available
2024-02-20T15:03:02Z
dc.date.issued
2023-04
dc.identifier.citation
Schattner, Mirta Ana; Sleep like a bear; American Association for the Advancement of Science; Science; 380; 6641; 4-2023; 133-134
dc.identifier.issn
0036-8075
dc.identifier.uri
http://hdl.handle.net/11336/227653
dc.description.abstract
Deep vein thrombosis (DVT) is a common feature of short-term immobilization, which occurs, for example, for patients with acute paralysis. However, in chronic immobilization—e.g., owing to spinal cord injury (SCI)—the incidence of DVT equals that in the general population (1). The mechanisms that protect against DVT during chronic immobilization in SCI patients are unknown. On page 178 of this issue, Thienel et al. (2) report an analysis of the thromboinflammatory machinery in hibernating brown bears (Ursus arctos), which rarely suffer from DVT despite 6 months of immobilization during hibernation (3). They found that platelets from hibernating bears exhibit an antithrombotic signature characterized by decreased expression of heat shock protein 47 (HSP47) and overall reduced biomarkers of thromboinflammation compared with those of active brown bears. Further, this signature is conserved across different animal species, including mice, pigs, and humans, suggesting that this could be a therapeutic target to reduce DVT in immobilized patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for the Advancement of Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
platelets
dc.subject
hsp47
dc.subject
thromboinflammation
dc.subject
venous thrombosis
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sleep like a bear
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-20T13:21:33Z
dc.journal.volume
380
dc.journal.number
6641
dc.journal.pagination
133-134
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/science.adh3276
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.adh3276
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