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dc.contributor.author
Chabay, Paola Andrea
dc.date.available
2024-02-20T14:45:31Z
dc.date.issued
2023-05
dc.identifier.citation
Chabay, Paola Andrea; Increasing microenvironment complexity in HL; American Society of Hematology; Blood; 141; 19; 5-2023; 2290-2291
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/227646
dc.description.abstract
cHL is unique among lymphoid malignancies, given that malignant HRSC comprise less than 1% of the total cell population. HRSC secrete chemokines and cytokines that drive the formation of a complex microenvironment of nontumor cells. This microenvironment consists of both innate as well as adaptive immune cells.2 The extensive but ineffective immune cell infiltrates found in cHL suggest that HRSC have developed mechanisms to escape immunosurveillance. Furthermore, HRSC depend on microenvironmental signals for survival and growth. Even though many cHL patients are cured with current treatment regimens, 20% to 30% fail to respond or experience a relapse after treatment. Moreover, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity are persistent challenges requiring more basic research to identify new therapeutic targets, particularly within this unique microenvironment.3,4 Stewart et al provide evidence for the first time of the expression of immunoregulatory checkpoints and the secretion of chemokines from previously uncharacterized cells that contribute to the exhaustion of T cells and contribute to immune evasion in cHL.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Hematology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hodgkin lymphoma
dc.subject
microenvironment
dc.subject.classification
Patología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Increasing microenvironment complexity in HL
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-20T13:23:25Z
dc.journal.volume
141
dc.journal.number
19
dc.journal.pagination
2290-2291
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina
dc.journal.title
Blood
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1182/blood.2023019661
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ashpublications.org/blood/article/141/19/2290/495579/Increasing-microenvironment-complexity-in-HL
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