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dc.contributor.author
Mojica, María Fernanda
dc.contributor.author
De La Cadena, Elsa
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García Betancur, Juan Carlos
dc.contributor.author
Porras, Jessica
dc.contributor.author
Novoa Caicedo, Isabella
dc.contributor.author
Páez Zamora, Laura
dc.contributor.author
Pallares, Christian
dc.contributor.author
Appel, Tobias Manuel
dc.contributor.author
Radice, Marcela Alejandra
dc.contributor.author
Castañeda Méndez, Paulo
dc.contributor.author
Gales, Ana C.
dc.contributor.author
Munita, José M.
dc.contributor.author
Villegas, María Virginia
dc.date.available
2024-02-20T12:32:20Z
dc.date.issued
2023-04
dc.identifier.citation
Mojica, María Fernanda; De La Cadena, Elsa; García Betancur, Juan Carlos; Porras, Jessica; Novoa Caicedo, Isabella; et al.; Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals; American Society for Microbiology; mSphere; 8; 2; 4-2023; 1-10
dc.identifier.uri
http://hdl.handle.net/11336/227554
dc.description.abstract
Ceftazidime-avibactam (CZA) is the combination of a third-generation cephalosporin and a new non-b-lactam b-lactamase inhibitor capable of inactivating class A, C, and some D b-lactamases. From a collection of 2,727 clinical isolates of Enterobacterales (n = 2,235) and P. aeruginosa (n = 492) that were collected between 2016 and 2017 from five Latin American countries, we investigated the molecular resistance mechanisms to CZA of 127 (18/2,235 [0.8%] Enterobacterales and 109/492 [22.1%] P. aeruginosa). First, by qPCR for the presence of genes encoding KPC, NDM, VIM, IMP, OXA-48-like, and SPM-1 carbapenemases, and second, by whole-genome sequencing (WGS). From the CZA-resistant isolates, MBL-encoding genes were detected in all 18 Enterobacterales and 42/109 P. aeruginosa isolates, explaining their resistant phenotype. Resistant isolates that yielded a negative qPCR result for any of the MBL encoding genes were subjected to WGS. The WGS analysis of the 67 remaining P. aeruginosa isolates showed mutations in genes previously associated with reduced susceptibility to CZA, such as those involved in the MexAB-OprM efflux pump and AmpC (PDC) hyperproduction, PoxB (blaOXA-50-like), FtsI (PBP3), DacB (PBP4), and OprD. The results presented here offer a snapshot of the molecular epidemiological landscape for CZA resistance before the introduction of this antibiotic into the Latin American market. Therefore, these results serve as a valuable comparison tool to trace the evolution of the resistance to CZA in this carbapenemase-endemic geographical region.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIMICROBIAL RESISTANCE
dc.subject
CEFTAZIDIME/AVIBACTAM
dc.subject
ENTEROBACTERALES
dc.subject
LATIN AMERICA
dc.subject
PSEUDOMONAS AERUGINOSA
dc.subject.classification
Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-25T14:05:03Z
dc.identifier.eissn
2379-5042
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Mojica, María Fernanda. Case Western Reserve University; Estados Unidos. Va Northeast Ohio Healthcare System; Estados Unidos. Universidad El Bosque;
dc.description.fil
Fil: De La Cadena, Elsa. Universidad El Bosque;
dc.description.fil
Fil: García Betancur, Juan Carlos. Universidad El Bosque;
dc.description.fil
Fil: Porras, Jessica. Universidad El Bosque;
dc.description.fil
Fil: Novoa Caicedo, Isabella. Universidad El Bosque;
dc.description.fil
Fil: Páez Zamora, Laura. Universidad El Bosque;
dc.description.fil
Fil: Pallares, Christian. Universidad El Bosque;
dc.description.fil
Fil: Appel, Tobias Manuel. Universidad El Bosque;
dc.description.fil
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Castañeda Méndez, Paulo. Hospital San Ángel Inn Universidad; México. Fundacion Clinica Medica Sur; México
dc.description.fil
Fil: Gales, Ana C.. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Munita, José M.. Millennium Initiative for Collaborative Research on Bacterial Resistance; Chile
dc.description.fil
Fil: Villegas, María Virginia. Universidad El Bosque;
dc.journal.title
mSphere
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/msphere.00651-22
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/msphere.00651-22
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