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dc.contributor.author
Garnero, Claudia
dc.contributor.author
Aloisio, Carolina
dc.contributor.author
Longhi, Marcela Raquel
dc.date.available
2017-08-18T21:46:14Z
dc.date.issued
2013-02
dc.identifier.citation
Garnero, Claudia; Aloisio, Carolina; Longhi, Marcela Raquel; Ibuprofen-maltodextrin interaction: study of enantiomeric recognition and complex characterization; Scientific Research; Pharmacology & Pharmacy; 4; 1; 2-2013; 18-30; 26863
dc.identifier.issn
2157-9431
dc.identifier.uri
http://hdl.handle.net/11336/22735
dc.description.abstract
The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance spectroscopy experiments and solubility studies. The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending. These solid systems were characterized in the solid state using differential scanning calorimetry, thermogravimetric analysis, Fourier Transform-Infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Detailed nuclear magnetic resonance studies provided evidence of the influence of the type and concentration of the maltodextrin host on the chiral recognition of racemic ibuprofen, indicating that these linear ligands act as chiral selectors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ibuprofen
dc.subject
Maltodextrin
dc.subject
Chiral Recognition
dc.subject
Complex Characterization
dc.subject.classification
Nano-materiales
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Ibuprofen-maltodextrin interaction: study of enantiomeric recognition and complex characterization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-18T14:59:23Z
dc.journal.volume
4
dc.journal.number
1
dc.journal.pagination
18-30; 26863
dc.journal.pais
China
dc.description.fil
Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Aloisio, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Pharmacology & Pharmacy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/pp.2013.41003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://file.scirp.org/Html/3-2500220_26863.htm
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