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dc.contributor.author
Etcheverry, María Eugenia
dc.contributor.author
Pasquale, Miguel Angel
dc.contributor.author
Garavaglia, Mario Jose
dc.date.available
2024-02-16T14:47:47Z
dc.date.issued
2023-06
dc.identifier.citation
Etcheverry, María Eugenia; Pasquale, Miguel Angel; Garavaglia, Mario Jose; Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence; Journal of Clinical Studies and Medical Images, Case Reports; Journal of Clinical Studies and Medical Images, Case Reports; 1; 3; 1013; 6-2023; 1-5
dc.identifier.uri
http://hdl.handle.net/11336/227243
dc.description.abstract
The main objective of the present study was to develop a violet LED light source suitable for medical application devoted to the diagnostic and treatment of non-melanoma skin cancers. For this propose, we constructed a 12 W violet LED lamp (with maximum emission peak at 405 nm) made up of four mobile 3 W LED. The LED lamp was characterized employing a spectrometer coupled to an optical fiber. The irradiance, the radiant power and the radiant intensity for different distances between the lamp and the detector was assessed. Data were compared with a simulated LED lamp by using the Zemax optic software for the realization of luminaries with the desired characteristics as required for medical applications.The developed lamp in combination with a portable spectrometer was employed under medical supervision to detect differences in the emission spectrum of skin suspicious regions and healthy ones of a patient with non-melanoma skin cancer. The light of the LED lamp was concentrated in the examined region by means of the proper focusing of the four individual LEDs, rendering a high intensity homogeneous spot. Thus, endogenous chromophores at the skin were excited, and the emission intensity appeared to be enough to detect an enhanced peaked structure around 600 nm for some suspicious regions before treatment, and that were absence in healthy regions. These differences can be related to the augmented protoporphyrin IX content in neoplastic regions. Results presented in this work indicates the usefulness of the developed LED lamp as an easy-to-use device for the non-invasive detection of skin neoplastic pathologies, before and after treatment, with the aim of better define the malignant regions as well as predict the outcome of a certain treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Journal of Clinical Studies and Medical Images, Case Reports
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NON-MELANOMA SKIN CANCER
dc.subject
ONE-POINT FLUORESCENCE DETECTION
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VIOLET LED LAMP
dc.subject.classification
Otras Medicina Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-14T12:37:13Z
dc.identifier.eissn
2837-7567
dc.journal.volume
1
dc.journal.number
3; 1013
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Texas
dc.description.fil
Fil: Etcheverry, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
dc.description.fil
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Garavaglia, Mario Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
dc.journal.title
Journal of Clinical Studies and Medical Images, Case Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jcsmicasereports.org/articles/JCSMICR-1013.pdf
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