Artículo
Can a gem -Diol Moiety Be Isolated? A Reaction Study by NMR and X-ray Spectroscopies
Fecha de publicación:
10/2023
Editorial:
American Chemical Society
Revista:
Journal Of Chemical Education
ISSN:
0021-9584
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a gem-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of gem-diols is not usually covered in depth in organic chemistry courses. Herein, we propose a two-step activity to study the isolation of different gem-diols: an organic laboratory practice designed for undergraduate students combined with an in-class activity. The approach focuses on the study of heterocyclic compounds with aldehyde moieties using solution and solid-state nuclear magnetic resonance combined with X-ray crystallography.
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Articulos(CETMIC)
Articulos de CENTRO TECNOL.DE REC.MINERALES Y CERAMICA (I)
Articulos de CENTRO TECNOL.DE REC.MINERALES Y CERAMICA (I)
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Crespi, Ayelen Florencia; Lazaro Martinez, Juan Manuel; Can a gem -Diol Moiety Be Isolated? A Reaction Study by NMR and X-ray Spectroscopies; American Chemical Society; Journal Of Chemical Education; 100; 11; 10-2023; 4536-4542
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