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Evento

Fructose -induced maternal metabolic syndrome leads to cerebral oxidative stress, neuroinflammation and neurobehavioral impairments in offspring

Prado Spalm, Facundo HeberIcon ; Cuervo Sanchez, Marie LuciaIcon ; Furland, Natalia EdithIcon ; Valles, Ana SofiaIcon
Colaboradores: Alonso, Daniel FernandoIcon ; Malchiodi, Emilio LuisIcon ; Vila Petroff, Martin GerardeIcon ; Lamb, Caroline AnaIcon
Tipo del evento: Reunión
Nombre del evento: Reunión Conjunta SAIC SAI & FAIC SAFIS 2022; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología; Reunión Anual 2022 de la Sociedad Argentina de Fisiología
Fecha del evento: 16/11/2022
Institución Organizadora: Sociedad Argentina de Investigación Clínica; Sociedad Argentina de Inmunología; Sociedad Argentina de Fisiología;
Título de la revista: Medicina (Buenos Aires)
Editorial: Fundación Revista Medicina
ISSN: 0025-7680
e-ISSN: 1669-9106
Idioma: Inglés
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Since fructose (F) consumption has been linked to the aetiology of metabolic syndrome (MetS), we studied the implications of long- term effects of F consumption by dams on rat offspring neurode- velopment and neurobehavior. Two-month-old Wistar rats were fed standard chow and drank water (control, C) or 20% F (ad libitum) for 10 weeks before mating and throughout pregnancy and lactation. In dams, macronutrient and caloric intake were calculated and blood samples were collected for biochemical analysis. At postnatal day 1 (PN1) oxidative and inflammatory brain status were evaluated in male (♂) and female (♀) pups. The remaining litters (reduced to 8 pups with equal sex ratios) were reassigned to a nursing dam from the C group (NC) or from the F group (NF). Offspring were evaluat- ed for sensorimotor reflexes, reciprocal social interaction, memory retention, novel object recognition and nociception. A p value <0.05 was regarded as statistically significant. F consumption in dams in- duced MetS, increased caloric and carbohydrate intake and reduced protein and fat consumption. Weight, waist circumference and fat % were also higher in F dams. At PN1, ♀ from the F group showed enhanced lipid peroxidation (TBARS) levels, elevated catalase ac- tivity and increased superoxide dismutase protein expression in the whole brain. Neuroinflammation was corroborated by increased pro- tein expression of cyclooxygenase 2. The acquisition of developing milestones was delayed in ♀ from F-NC and F-NF groups. In com- parison with C-NC litter, aggressive social behavior increased while memory retention and nociception were reduced in offspring from F-NC. The ability of recognizing a previously presented stimulus was affected only in ♂ from the F-NC group. These findings suggest that F-induced maternal MetS results in offspring neurodevelopmen- tal delay and neurobehavioral changes probably associated with early brain oxidative stress and inflammation. Interestingly, offspring gender differences were noted
Palabras clave: dieta alta en fructosa , síndrome metabólico materno , neurodesarrollo , comportamiento
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/227135
URL: https://www.saic.org.ar/revista-medicina
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Eventos(INIBIBB)
Eventos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Fructose -induced maternal metabolic syndrome leads to cerebral oxidative stress, neuroinflammation and neurobehavioral impairments in offspring; Reunión Conjunta SAIC SAI & FAIC SAFIS 2022; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología; Reunión Anual 2022 de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 185-185
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